Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence

Background: Opioid use disorder (OUD) negatively impacts the HIV continuum of care for persons living with HIV (PLH). Medication treatment for OUD (MOUD) may have differential biological effects in individuals with HIV and OUD. To understand the role of MOUD – opioid agonist methadone, partial agoni...

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Autores principales:	Alysse Schultheis, Mark Sanchez, Savannah Pedersen, Tassos Kyriakides, Ya-Chi Ho, Yuval Kluger, Sandra A. Springer
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Opioid use disorder HIV Medication treatment for opioid use disorder Extended-release naltrexone Buprenorphine Methadone Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2814f92706174e649e0ad90fdfc5205c
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spelling	oai:doaj.org-article:2814f92706174e649e0ad90fdfc5205c2021-11-14T04:34:43ZDesign and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence2451-865410.1016/j.conctc.2021.100866https://doaj.org/article/2814f92706174e649e0ad90fdfc5205c2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2451865421001666https://doaj.org/toc/2451-8654Background: Opioid use disorder (OUD) negatively impacts the HIV continuum of care for persons living with HIV (PLH). Medication treatment for OUD (MOUD) may have differential biological effects in individuals with HIV and OUD. To understand the role of MOUD – opioid agonist methadone, partial agonist buprenorphine and antagonist naltrexone – in HIV-1 persistence and reactivation, we will use molecular virology approaches to carry out the first prospective, longitudinal studies of adults living with HIV with OUD initiating MOUD. One of the major challenges to studying the impact of MOUD on HIV persistence is the low retention rate of study participants and the requirement of large-volume blood sampling to study the HIV proviral landscape and expression profiles. Methods: A prospective cohort study is underway to study the HIV-1 expression, proviral landscape, and clonal expansion dynamics using limited blood sampling from persons with DSM-5 diagnosed OUD who are living with HIV infection and initiating treatment with methadone, buprenorphine, or extended-release naltrexone. Results: We describe the recruitment, laboratory, and statistical methods of this study as well as the protocol details of this on-going study. Out of the 510 screened for enrollment into the study, 35 (7%) were eligible and 27 were enrolled thus far. Retention through month 3 has been high at 95%. Conclusions: This on-going study is evaluating the impact of MOUD on HIV persistence at the molecular virology level using limited blood sampling via a prospective, longitudinal study of people living with HIV DSM-5 OUD initiating treatment with MOUD.Alysse SchultheisMark SanchezSavannah PedersenTassos KyriakidesYa-Chi HoYuval KlugerSandra A. SpringerElsevierarticleOpioid use disorderHIVMedication treatment for opioid use disorderExtended-release naltrexoneBuprenorphineMethadoneMedicine (General)R5-920ENContemporary Clinical Trials Communications, Vol 24, Iss , Pp 100866- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Opioid use disorder HIV Medication treatment for opioid use disorder Extended-release naltrexone Buprenorphine Methadone Medicine (General) R5-920
spellingShingle	Opioid use disorder HIV Medication treatment for opioid use disorder Extended-release naltrexone Buprenorphine Methadone Medicine (General) R5-920 Alysse Schultheis Mark Sanchez Savannah Pedersen Tassos Kyriakides Ya-Chi Ho Yuval Kluger Sandra A. Springer Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence
description	Background: Opioid use disorder (OUD) negatively impacts the HIV continuum of care for persons living with HIV (PLH). Medication treatment for OUD (MOUD) may have differential biological effects in individuals with HIV and OUD. To understand the role of MOUD – opioid agonist methadone, partial agonist buprenorphine and antagonist naltrexone – in HIV-1 persistence and reactivation, we will use molecular virology approaches to carry out the first prospective, longitudinal studies of adults living with HIV with OUD initiating MOUD. One of the major challenges to studying the impact of MOUD on HIV persistence is the low retention rate of study participants and the requirement of large-volume blood sampling to study the HIV proviral landscape and expression profiles. Methods: A prospective cohort study is underway to study the HIV-1 expression, proviral landscape, and clonal expansion dynamics using limited blood sampling from persons with DSM-5 diagnosed OUD who are living with HIV infection and initiating treatment with methadone, buprenorphine, or extended-release naltrexone. Results: We describe the recruitment, laboratory, and statistical methods of this study as well as the protocol details of this on-going study. Out of the 510 screened for enrollment into the study, 35 (7%) were eligible and 27 were enrolled thus far. Retention through month 3 has been high at 95%. Conclusions: This on-going study is evaluating the impact of MOUD on HIV persistence at the molecular virology level using limited blood sampling via a prospective, longitudinal study of people living with HIV DSM-5 OUD initiating treatment with MOUD.
format	article
author	Alysse Schultheis Mark Sanchez Savannah Pedersen Tassos Kyriakides Ya-Chi Ho Yuval Kluger Sandra A. Springer
author_facet	Alysse Schultheis Mark Sanchez Savannah Pedersen Tassos Kyriakides Ya-Chi Ho Yuval Kluger Sandra A. Springer
author_sort	Alysse Schultheis
title	Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence
title_short	Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence
title_full	Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence
title_fullStr	Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence
title_full_unstemmed	Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence
title_sort	design and implementation of a cohort study of persons living with hiv infection who are initiating medication treatment for opioid use disorder to evaluate hiv-1 persistence
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2814f92706174e649e0ad90fdfc5205c
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Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence

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