Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue

The ability to measure strain in cells and tissues in vitro with minimal perturbation and at high spatial resolution has proven challenging. Here the authors develop a fluorescently-labelled fibronectin square lattice mesh that can be applied to the surface of cells and tissues to enable direct quan...

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Autores principales:	Daniel J. Shiwarski, Joshua W. Tashman, Alkiviadis Tsamis, Jaci M. Bliley, Malachi A. Blundon, Edgar Aranda-Michel, Quentin Jallerat, John M. Szymanski, Brooke M. McCartney, Adam W. Feinberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28151620b7624dc4ac37b410cb88662e
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spelling	oai:doaj.org-article:28151620b7624dc4ac37b410cb88662e2021-12-02T15:39:09ZFibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue10.1038/s41467-020-19659-z2041-1723https://doaj.org/article/28151620b7624dc4ac37b410cb88662e2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19659-zhttps://doaj.org/toc/2041-1723The ability to measure strain in cells and tissues in vitro with minimal perturbation and at high spatial resolution has proven challenging. Here the authors develop a fluorescently-labelled fibronectin square lattice mesh that can be applied to the surface of cells and tissues to enable direct quantification and mapping of strain over time.Daniel J. ShiwarskiJoshua W. TashmanAlkiviadis TsamisJaci M. BlileyMalachi A. BlundonEdgar Aranda-MichelQuentin JalleratJohn M. SzymanskiBrooke M. McCartneyAdam W. FeinbergNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel J. Shiwarski Joshua W. Tashman Alkiviadis Tsamis Jaci M. Bliley Malachi A. Blundon Edgar Aranda-Michel Quentin Jallerat John M. Szymanski Brooke M. McCartney Adam W. Feinberg Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue
description	The ability to measure strain in cells and tissues in vitro with minimal perturbation and at high spatial resolution has proven challenging. Here the authors develop a fluorescently-labelled fibronectin square lattice mesh that can be applied to the surface of cells and tissues to enable direct quantification and mapping of strain over time.
format	article
author	Daniel J. Shiwarski Joshua W. Tashman Alkiviadis Tsamis Jaci M. Bliley Malachi A. Blundon Edgar Aranda-Michel Quentin Jallerat John M. Szymanski Brooke M. McCartney Adam W. Feinberg
author_facet	Daniel J. Shiwarski Joshua W. Tashman Alkiviadis Tsamis Jaci M. Bliley Malachi A. Blundon Edgar Aranda-Michel Quentin Jallerat John M. Szymanski Brooke M. McCartney Adam W. Feinberg
author_sort	Daniel J. Shiwarski
title	Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue
title_short	Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue
title_full	Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue
title_fullStr	Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue
title_full_unstemmed	Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue
title_sort	fibronectin-based nanomechanical biosensors to map 3d surface strains in live cells and tissue
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/28151620b7624dc4ac37b410cb88662e
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Fibronectin-based nanomechanical biosensors to map 3D surface strains in live cells and tissue

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