Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia

Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammato...

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Autores principales:	Fatma Tokat, Julia S. Lehman, Emel Dikicioglu Cetin, Engin Sezer, Umit Ince, Emel Ozturk Durmaz
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2018
Materias:	angiolymphoid hyperplasia with eosinophilia Wilms tumor 1 GLUT-1 hemangioma Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/2816126caefa4796886530e9e675cbe3
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spelling	oai:doaj.org-article:2816126caefa4796886530e9e675cbe32021-11-17T08:30:23ZImmunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia 10.5826/dpc.0801a062160-9381https://doaj.org/article/2816126caefa4796886530e9e675cbe32018-01-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/361https://doaj.org/toc/2160-9381 Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammatory process. Aim: Recently, the intracytoplasmic staining pattern of Wilms tumor 1 (WT1) on immunohistochemistry has highlighted true vascular neoplasms, such as microvenular hemangioma, tufted angioma, and spindle cell hemangioma, which has made it helpful to distinguish ALHE from vascular malformations, as there is a negative staining pattern in the other entities. We aimed to investigate the immunoreactivity of ALHE specimens for WT1 as well as glucose transporter protein 1 (GLUT1) immunohistochemistry, an important and sensitive marker for the diagnosis of infantile hemangioma, which recently has been described to label other hemangiomas, such as verrucous hemangioma. Material and methods: Clinical data and histopathological specimens from patients diagnosed with ALHE were reviewed, and immunohistochemical staining and microscopic analysis for WT-1 and GLUT1 were performed. Results: Intracytoplasmic endothelial staining of WT1 was detected in 19 of 20 ALHE specimens. GLUT1 was not detected in any ALHE specimen. Conclusions: We conclude that ALHE may represent a true hemangioma (i.e., benign vascular neoplasia) characterized by an eosinophil- and lymphocyte-rich inflammatory component as opposed to the reactive inflammatory dermatosis with a positive intracytoplasmic staining pattern for WT1. As far as we are aware, WT1 staining for ALHE has not been described to date. Fatma TokatJulia S. LehmanEmel Dikicioglu CetinEngin SezerUmit InceEmel Ozturk DurmazMattioli1885articleangiolymphoid hyperplasia with eosinophiliaWilms tumor 1GLUT-1hemangiomaDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 8, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiolymphoid hyperplasia with eosinophilia Wilms tumor 1 GLUT-1 hemangioma Dermatology RL1-803
spellingShingle	angiolymphoid hyperplasia with eosinophilia Wilms tumor 1 GLUT-1 hemangioma Dermatology RL1-803 Fatma Tokat Julia S. Lehman Emel Dikicioglu Cetin Engin Sezer Umit Ince Emel Ozturk Durmaz Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia
description	Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammatory process. Aim: Recently, the intracytoplasmic staining pattern of Wilms tumor 1 (WT1) on immunohistochemistry has highlighted true vascular neoplasms, such as microvenular hemangioma, tufted angioma, and spindle cell hemangioma, which has made it helpful to distinguish ALHE from vascular malformations, as there is a negative staining pattern in the other entities. We aimed to investigate the immunoreactivity of ALHE specimens for WT1 as well as glucose transporter protein 1 (GLUT1) immunohistochemistry, an important and sensitive marker for the diagnosis of infantile hemangioma, which recently has been described to label other hemangiomas, such as verrucous hemangioma. Material and methods: Clinical data and histopathological specimens from patients diagnosed with ALHE were reviewed, and immunohistochemical staining and microscopic analysis for WT-1 and GLUT1 were performed. Results: Intracytoplasmic endothelial staining of WT1 was detected in 19 of 20 ALHE specimens. GLUT1 was not detected in any ALHE specimen. Conclusions: We conclude that ALHE may represent a true hemangioma (i.e., benign vascular neoplasia) characterized by an eosinophil- and lymphocyte-rich inflammatory component as opposed to the reactive inflammatory dermatosis with a positive intracytoplasmic staining pattern for WT1. As far as we are aware, WT1 staining for ALHE has not been described to date.
format	article
author	Fatma Tokat Julia S. Lehman Emel Dikicioglu Cetin Engin Sezer Umit Ince Emel Ozturk Durmaz
author_facet	Fatma Tokat Julia S. Lehman Emel Dikicioglu Cetin Engin Sezer Umit Ince Emel Ozturk Durmaz
author_sort	Fatma Tokat
title	Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia
title_short	Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia
title_full	Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia
title_fullStr	Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia
title_full_unstemmed	Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia
title_sort	immunoreactivity of wilms tumor 1 (wt1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia
publisher	Mattioli1885
publishDate	2018
url	https://doaj.org/article/2816126caefa4796886530e9e675cbe3
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Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia

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