Association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma

Abstract To investigate the association of peripheral anterior synechiae (PAS) with intraocular pressure (IOP) and anterior-segment parameters in subjects with primary angle-closure glaucoma (PACG). A total of 267 subjects with PACG were recruited and underwent gonioscopy and anterior-segment optica...

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Autores principales:	Yunhua Loo, Tin A. Tun, Eranga N. Vithana, Shamira A. Perera, Rahat Husain, Tina T. Wong, Tin Aung, Monisha E. Nongpiur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/281878c48f8a46b5b5405f178fbe5724
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spelling	oai:doaj.org-article:281878c48f8a46b5b5405f178fbe57242021-12-02T18:34:06ZAssociation of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma10.1038/s41598-021-93293-72045-2322https://doaj.org/article/281878c48f8a46b5b5405f178fbe57242021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93293-7https://doaj.org/toc/2045-2322Abstract To investigate the association of peripheral anterior synechiae (PAS) with intraocular pressure (IOP) and anterior-segment parameters in subjects with primary angle-closure glaucoma (PACG). A total of 267 subjects with PACG were recruited and underwent gonioscopy and anterior-segment optical coherence tomography (ASOCT). Customized software was used to measure ASOCT parameters, including angle opening distance (AOD750) and trabecular-iris-space-area (TISA750) at 750 µm from the scleral spur, anterior chamber depth, width, area and volume (ACD, ACW, ACA, ACV), iris thickness (IT750), iris area (IAREA), and lens vault (LV). Presenting IOP was defined as the first IOP reading before the initiation of IOP-lowering treatment. The mean age of the 267 subjects was 67.0 ± 8.9 years, 140 (52.4%) were male, and 246 (92.1%) were of Chinese ethnicity. PAS was present in 122 (45.7%) subjects, and was most frequently found in the superior quadrant (79.5%). Subjects with PAS had greater presenting IOP (28.7 ± 12.9 vs 22.4 ± 9.7 mmHg, p < 0.001), narrower AOD750 (p < 0.001), smaller TISA750 (p < 0.001), ACD (p = 0.04), ACA (p = 0.02), ACV (p = 0.01) and larger LV (p = 0.01) compared to PACG eyes without PAS. No significant differences were noted for iris parameters. A multivariate logistic regression analysis showed that higher presenting IOP (β = 0.20, p < 0.001), worse visual field mean deviation (β = − 0.20, p = 0.01) and narrower AOD750 (β = − 0.25, p = 0.03) were the only parameters that significantly correlated with the extent of PAS in clock hours. Almost one-half of the subjects with PACG demonstrated PAS; these eyes were associated with higher presenting IOP, smaller anterior segment dimensions and more severe disease.Yunhua LooTin A. TunEranga N. VithanaShamira A. PereraRahat HusainTina T. WongTin AungMonisha E. NongpiurNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yunhua Loo Tin A. Tun Eranga N. Vithana Shamira A. Perera Rahat Husain Tina T. Wong Tin Aung Monisha E. Nongpiur Association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma
description	Abstract To investigate the association of peripheral anterior synechiae (PAS) with intraocular pressure (IOP) and anterior-segment parameters in subjects with primary angle-closure glaucoma (PACG). A total of 267 subjects with PACG were recruited and underwent gonioscopy and anterior-segment optical coherence tomography (ASOCT). Customized software was used to measure ASOCT parameters, including angle opening distance (AOD750) and trabecular-iris-space-area (TISA750) at 750 µm from the scleral spur, anterior chamber depth, width, area and volume (ACD, ACW, ACA, ACV), iris thickness (IT750), iris area (IAREA), and lens vault (LV). Presenting IOP was defined as the first IOP reading before the initiation of IOP-lowering treatment. The mean age of the 267 subjects was 67.0 ± 8.9 years, 140 (52.4%) were male, and 246 (92.1%) were of Chinese ethnicity. PAS was present in 122 (45.7%) subjects, and was most frequently found in the superior quadrant (79.5%). Subjects with PAS had greater presenting IOP (28.7 ± 12.9 vs 22.4 ± 9.7 mmHg, p < 0.001), narrower AOD750 (p < 0.001), smaller TISA750 (p < 0.001), ACD (p = 0.04), ACA (p = 0.02), ACV (p = 0.01) and larger LV (p = 0.01) compared to PACG eyes without PAS. No significant differences were noted for iris parameters. A multivariate logistic regression analysis showed that higher presenting IOP (β = 0.20, p < 0.001), worse visual field mean deviation (β = − 0.20, p = 0.01) and narrower AOD750 (β = − 0.25, p = 0.03) were the only parameters that significantly correlated with the extent of PAS in clock hours. Almost one-half of the subjects with PACG demonstrated PAS; these eyes were associated with higher presenting IOP, smaller anterior segment dimensions and more severe disease.
format	article
author	Yunhua Loo Tin A. Tun Eranga N. Vithana Shamira A. Perera Rahat Husain Tina T. Wong Tin Aung Monisha E. Nongpiur
author_facet	Yunhua Loo Tin A. Tun Eranga N. Vithana Shamira A. Perera Rahat Husain Tina T. Wong Tin Aung Monisha E. Nongpiur
author_sort	Yunhua Loo
title	Association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma
title_short	Association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma
title_full	Association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma
title_fullStr	Association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma
title_full_unstemmed	Association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma
title_sort	association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/281878c48f8a46b5b5405f178fbe5724
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Association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma

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