Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b

Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) is important for invasion of reticulocytes and PvRBP2b antibodies correlate with protection. Here, Chan et al. isolate and characterize anti-PvRBP2b human monoclonal antibodies and describe mechanisms by which these antibodies inhibit invasi...

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Autores principales: Li-Jin Chan, Anugraha Gandhirajan, Lenore L. Carias, Melanie H. Dietrich, Oscar Vadas, Remy Visentin, Camila T. França, Sebastien Menant, Dominique Soldati-Favre, Ivo Mueller, Christopher L. King, Wai-Hong Tham
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/281a04da1cad4cea92f1a8e4257187e0
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Sumario:Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) is important for invasion of reticulocytes and PvRBP2b antibodies correlate with protection. Here, Chan et al. isolate and characterize anti-PvRBP2b human monoclonal antibodies and describe mechanisms by which these antibodies inhibit invasion.