CRISPRoff enables spatio-temporal control of CRISPR editing

CRISPRoff enables spatio-temporal control of CRISPR editing

Uncontrolled gene editing can lead to off-target effects and chromosomal translocations. Here the authors develop CRISPRoff, light degradable sgRNAs for titratable and spatially defined gene editing.

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Auteurs principaux: Jared Carlson-Stevermer, Reed Kelso, Anastasia Kadina, Sahil Joshi, Nicholas Rossi, John Walker, Rich Stoner, Travis Maures
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Science
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Accès en ligne:https://doaj.org/article/281b8bfd5bf6470ba784a46dec47a11d
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Résumé:Uncontrolled gene editing can lead to off-target effects and chromosomal translocations. Here the authors develop CRISPRoff, light degradable sgRNAs for titratable and spatially defined gene editing.

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