CRISPRoff enables spatio-temporal control of CRISPR editing

CRISPRoff enables spatio-temporal control of CRISPR editing

Uncontrolled gene editing can lead to off-target effects and chromosomal translocations. Here the authors develop CRISPRoff, light degradable sgRNAs for titratable and spatially defined gene editing.

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Bibliographic Details
Main Authors: Jared Carlson-Stevermer, Reed Kelso, Anastasia Kadina, Sahil Joshi, Nicholas Rossi, John Walker, Rich Stoner, Travis Maures
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/281b8bfd5bf6470ba784a46dec47a11d
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Summary:Uncontrolled gene editing can lead to off-target effects and chromosomal translocations. Here the authors develop CRISPRoff, light degradable sgRNAs for titratable and spatially defined gene editing.

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