CRISPRoff enables spatio-temporal control of CRISPR editing

CRISPRoff enables spatio-temporal control of CRISPR editing

Uncontrolled gene editing can lead to off-target effects and chromosomal translocations. Here the authors develop CRISPRoff, light degradable sgRNAs for titratable and spatially defined gene editing.

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Autores principales: Jared Carlson-Stevermer, Reed Kelso, Anastasia Kadina, Sahil Joshi, Nicholas Rossi, John Walker, Rich Stoner, Travis Maures
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/281b8bfd5bf6470ba784a46dec47a11d
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spelling oai:doaj.org-article:281b8bfd5bf6470ba784a46dec47a11d2021-12-02T18:07:54ZCRISPRoff enables spatio-temporal control of CRISPR editing10.1038/s41467-020-18853-32041-1723https://doaj.org/article/281b8bfd5bf6470ba784a46dec47a11d2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18853-3https://doaj.org/toc/2041-1723Uncontrolled gene editing can lead to off-target effects and chromosomal translocations. Here the authors develop CRISPRoff, light degradable sgRNAs for titratable and spatially defined gene editing.Jared Carlson-StevermerReed KelsoAnastasia KadinaSahil JoshiNicholas RossiJohn WalkerRich StonerTravis MauresNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jared Carlson-Stevermer
Reed Kelso
Anastasia Kadina
Sahil Joshi
Nicholas Rossi
John Walker
Rich Stoner
Travis Maures
CRISPRoff enables spatio-temporal control of CRISPR editing
description Uncontrolled gene editing can lead to off-target effects and chromosomal translocations. Here the authors develop CRISPRoff, light degradable sgRNAs for titratable and spatially defined gene editing.
format article
author Jared Carlson-Stevermer
Reed Kelso
Anastasia Kadina
Sahil Joshi
Nicholas Rossi
John Walker
Rich Stoner
Travis Maures
author_facet Jared Carlson-Stevermer
Reed Kelso
Anastasia Kadina
Sahil Joshi
Nicholas Rossi
John Walker
Rich Stoner
Travis Maures
author_sort Jared Carlson-Stevermer
title CRISPRoff enables spatio-temporal control of CRISPR editing
title_short CRISPRoff enables spatio-temporal control of CRISPR editing
title_full CRISPRoff enables spatio-temporal control of CRISPR editing
title_fullStr CRISPRoff enables spatio-temporal control of CRISPR editing
title_full_unstemmed CRISPRoff enables spatio-temporal control of CRISPR editing
title_sort crisproff enables spatio-temporal control of crispr editing
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/281b8bfd5bf6470ba784a46dec47a11d
work_keys_str_mv AT jaredcarlsonstevermer crisproffenablesspatiotemporalcontrolofcrisprediting
AT reedkelso crisproffenablesspatiotemporalcontrolofcrisprediting
AT anastasiakadina crisproffenablesspatiotemporalcontrolofcrisprediting
AT sahiljoshi crisproffenablesspatiotemporalcontrolofcrisprediting
AT nicholasrossi crisproffenablesspatiotemporalcontrolofcrisprediting
AT johnwalker crisproffenablesspatiotemporalcontrolofcrisprediting
AT richstoner crisproffenablesspatiotemporalcontrolofcrisprediting
AT travismaures crisproffenablesspatiotemporalcontrolofcrisprediting
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