Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death

Feiyang Jin,1 Di Liu,1 Xiaoling Xu,1 Jiansong Ji,2 Yongzhong Du1 1Institute of Pharmaceutics, College of Pharmaceutics Sciences, Zhejiang University, Hangzhou, 310058, People’s Republic of China; 2Department of Radiology, Lishui Hospital of Zhejiang University, Lishui, 323000, People’s Republic of C...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jin F, Liu D, Xu X, Ji J, Du Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	photodynamic therapy immunogenic cell death antitumor immunity immunosuppressive tumor environment nanomedicines Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/281be5737ebc418e9a482b741ca74c84
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:281be5737ebc418e9a482b741ca74c84
record_format	dspace
spelling	oai:doaj.org-article:281be5737ebc418e9a482b741ca74c842021-12-02T18:48:06ZNanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death1178-2013https://doaj.org/article/281be5737ebc418e9a482b741ca74c842021-07-01T00:00:00Zhttps://www.dovepress.com/nanomaterials-based-photodynamic-therapy-with-combined-treatment-impro-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Feiyang Jin,1 Di Liu,1 Xiaoling Xu,1 Jiansong Ji,2 Yongzhong Du1 1Institute of Pharmaceutics, College of Pharmaceutics Sciences, Zhejiang University, Hangzhou, 310058, People’s Republic of China; 2Department of Radiology, Lishui Hospital of Zhejiang University, Lishui, 323000, People’s Republic of ChinaCorrespondence: Jiansong JiDepartment of Radiology, Lishui Hospital of Zhejiang University, Lishui, 323000, People’s Republic of ChinaTel +86-578-2285011Email lschrjjs@163.comYongzhong DuInstitute of Pharmaceutics, College of Pharmaceutics Sciences, Zhejiang University, 866 Yu-Hang-Tang Road, Hangzhou, 310058, People’s Republic of ChinaTel +86-571-88981651Email duyongzhong@zju.edu.cnAbstract: Benefiting from the rapid development of nanotechnology, photodynamic therapy (PDT) is arising as a novel non-invasive clinical treatment for specific cancers, which exerts direct efficacy in destroying primary tumors by generating excessive cytotoxic reactive oxygen species (ROS). Notably, PDT-induced cell death is related to T cell-mediated antitumor immune responses through induction of immunogenic cell death (ICD). However, ICD elicited via PDT is not strong enough and is limited by immunosuppressive tumor microenvironment (ITM). Therefore, it is necessary to improve PDT efficacy through enhancing ICD with the combination of synergistic tumor therapies. Herein, the recent progress of nanomaterials-based PDT combined with chemotherapy, photothermal therapy, radiotherapy, and immunotherapy, employing ICD-boosted treatments is reviewed. An outlook about the future application in clinics of nanomaterials-based PDT strategies is also mentioned.Keywords: photodynamic therapy, immunogenic cell death, antitumor immunity, immunosuppressive tumor environment, nanomedicinesJin FLiu DXu XJi JDu YDove Medical Pressarticlephotodynamic therapyimmunogenic cell deathantitumor immunityimmunosuppressive tumor environmentnanomedicinesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 4693-4712 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	photodynamic therapy immunogenic cell death antitumor immunity immunosuppressive tumor environment nanomedicines Medicine (General) R5-920
spellingShingle	photodynamic therapy immunogenic cell death antitumor immunity immunosuppressive tumor environment nanomedicines Medicine (General) R5-920 Jin F Liu D Xu X Ji J Du Y Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death
description	Feiyang Jin,1 Di Liu,1 Xiaoling Xu,1 Jiansong Ji,2 Yongzhong Du1 1Institute of Pharmaceutics, College of Pharmaceutics Sciences, Zhejiang University, Hangzhou, 310058, People’s Republic of China; 2Department of Radiology, Lishui Hospital of Zhejiang University, Lishui, 323000, People’s Republic of ChinaCorrespondence: Jiansong JiDepartment of Radiology, Lishui Hospital of Zhejiang University, Lishui, 323000, People’s Republic of ChinaTel +86-578-2285011Email lschrjjs@163.comYongzhong DuInstitute of Pharmaceutics, College of Pharmaceutics Sciences, Zhejiang University, 866 Yu-Hang-Tang Road, Hangzhou, 310058, People’s Republic of ChinaTel +86-571-88981651Email duyongzhong@zju.edu.cnAbstract: Benefiting from the rapid development of nanotechnology, photodynamic therapy (PDT) is arising as a novel non-invasive clinical treatment for specific cancers, which exerts direct efficacy in destroying primary tumors by generating excessive cytotoxic reactive oxygen species (ROS). Notably, PDT-induced cell death is related to T cell-mediated antitumor immune responses through induction of immunogenic cell death (ICD). However, ICD elicited via PDT is not strong enough and is limited by immunosuppressive tumor microenvironment (ITM). Therefore, it is necessary to improve PDT efficacy through enhancing ICD with the combination of synergistic tumor therapies. Herein, the recent progress of nanomaterials-based PDT combined with chemotherapy, photothermal therapy, radiotherapy, and immunotherapy, employing ICD-boosted treatments is reviewed. An outlook about the future application in clinics of nanomaterials-based PDT strategies is also mentioned.Keywords: photodynamic therapy, immunogenic cell death, antitumor immunity, immunosuppressive tumor environment, nanomedicines
format	article
author	Jin F Liu D Xu X Ji J Du Y
author_facet	Jin F Liu D Xu X Ji J Du Y
author_sort	Jin F
title	Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death
title_short	Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death
title_full	Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death
title_fullStr	Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death
title_full_unstemmed	Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death
title_sort	nanomaterials-based photodynamic therapy with combined treatment improves antitumor efficacy through boosting immunogenic cell death
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/281be5737ebc418e9a482b741ca74c84
work_keys_str_mv	AT jinf nanomaterialsbasedphotodynamictherapywithcombinedtreatmentimprovesantitumorefficacythroughboostingimmunogeniccelldeath AT liud nanomaterialsbasedphotodynamictherapywithcombinedtreatmentimprovesantitumorefficacythroughboostingimmunogeniccelldeath AT xux nanomaterialsbasedphotodynamictherapywithcombinedtreatmentimprovesantitumorefficacythroughboostingimmunogeniccelldeath AT jij nanomaterialsbasedphotodynamictherapywithcombinedtreatmentimprovesantitumorefficacythroughboostingimmunogeniccelldeath AT duy nanomaterialsbasedphotodynamictherapywithcombinedtreatmentimprovesantitumorefficacythroughboostingimmunogeniccelldeath
_version_	1718377611466375168

Nanomaterials-Based Photodynamic Therapy with Combined Treatment Improves Antitumor Efficacy Through Boosting Immunogenic Cell Death

Ejemplares similares