Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer
Following on reports that miR-424 expression promotes oncogenesis, Domenico Albino et al. find that extracellular vesicles (EVs) in the plasma of prostate cancer patients secrete miR-424. Using cell-based and animal models, they demonstrate that EV-mediated release of miR-424 can transfer oncogenic...
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Nature Portfolio
2021
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oai:doaj.org-article:28200d6da1754aecbc8751a32e04f9612021-12-02T13:57:57ZCirculating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer10.1038/s42003-020-01642-52399-3642https://doaj.org/article/28200d6da1754aecbc8751a32e04f9612021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01642-5https://doaj.org/toc/2399-3642Following on reports that miR-424 expression promotes oncogenesis, Domenico Albino et al. find that extracellular vesicles (EVs) in the plasma of prostate cancer patients secrete miR-424. Using cell-based and animal models, they demonstrate that EV-mediated release of miR-424 can transfer oncogenic signals across cells to promote recurrence and metastatic progression.Domenico AlbinoMartina FalcioneValeria UboldiDada Oluwaseyi TemilolaGiada SandriniJessica MerullaGianluca CivenniAleksandra KokanovicAlessandra StürchlerDheeraj ShindeMariangela GarofaloRicardo Pereira MestreVera ConstâncioMartha WiumJacopo BurrelloNicolò BaranziniAnnalisa GrimaldiJean-Philippe TheurillatDaniela BossiLucio BarileRui M. HenriqueCarmen JeronimoLuiz Fernando ZerbiniCarlo V. CatapanoGiuseppina M. CarboneNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Domenico Albino Martina Falcione Valeria Uboldi Dada Oluwaseyi Temilola Giada Sandrini Jessica Merulla Gianluca Civenni Aleksandra Kokanovic Alessandra Stürchler Dheeraj Shinde Mariangela Garofalo Ricardo Pereira Mestre Vera Constâncio Martha Wium Jacopo Burrello Nicolò Baranzini Annalisa Grimaldi Jean-Philippe Theurillat Daniela Bossi Lucio Barile Rui M. Henrique Carmen Jeronimo Luiz Fernando Zerbini Carlo V. Catapano Giuseppina M. Carbone Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer |
| description |
Following on reports that miR-424 expression promotes oncogenesis, Domenico Albino et al. find that extracellular vesicles (EVs) in the plasma of prostate cancer patients secrete miR-424. Using cell-based and animal models, they demonstrate that EV-mediated release of miR-424 can transfer oncogenic signals across cells to promote recurrence and metastatic progression. |
| format |
article |
| author |
Domenico Albino Martina Falcione Valeria Uboldi Dada Oluwaseyi Temilola Giada Sandrini Jessica Merulla Gianluca Civenni Aleksandra Kokanovic Alessandra Stürchler Dheeraj Shinde Mariangela Garofalo Ricardo Pereira Mestre Vera Constâncio Martha Wium Jacopo Burrello Nicolò Baranzini Annalisa Grimaldi Jean-Philippe Theurillat Daniela Bossi Lucio Barile Rui M. Henrique Carmen Jeronimo Luiz Fernando Zerbini Carlo V. Catapano Giuseppina M. Carbone |
| author_facet |
Domenico Albino Martina Falcione Valeria Uboldi Dada Oluwaseyi Temilola Giada Sandrini Jessica Merulla Gianluca Civenni Aleksandra Kokanovic Alessandra Stürchler Dheeraj Shinde Mariangela Garofalo Ricardo Pereira Mestre Vera Constâncio Martha Wium Jacopo Burrello Nicolò Baranzini Annalisa Grimaldi Jean-Philippe Theurillat Daniela Bossi Lucio Barile Rui M. Henrique Carmen Jeronimo Luiz Fernando Zerbini Carlo V. Catapano Giuseppina M. Carbone |
| author_sort |
Domenico Albino |
| title |
Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer |
| title_short |
Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer |
| title_full |
Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer |
| title_fullStr |
Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer |
| title_full_unstemmed |
Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer |
| title_sort |
circulating extracellular vesicles release oncogenic mir-424 in experimental models and patients with aggressive prostate cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/28200d6da1754aecbc8751a32e04f961 |
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