Could sensory mechanisms be a core factor that underlies freezing of gait in Parkinson's disease?

The main objective of this study was to determine how manipulating the amount of sensory information available about the body and surrounding environment influenced freezing of gait (FOG), while walking through a doorway. It was hypothesized that the more limited the sensory information, the greater...

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Autores principales:	Kaylena A Ehgoetz Martens, Frederico Pieruccini-Faria, Quincy J Almeida
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/28229962a560402595866380ec9d18a5
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spelling	oai:doaj.org-article:28229962a560402595866380ec9d18a52021-11-18T07:46:21ZCould sensory mechanisms be a core factor that underlies freezing of gait in Parkinson's disease?1932-620310.1371/journal.pone.0062602https://doaj.org/article/28229962a560402595866380ec9d18a52013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23667499/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The main objective of this study was to determine how manipulating the amount of sensory information available about the body and surrounding environment influenced freezing of gait (FOG), while walking through a doorway. It was hypothesized that the more limited the sensory information, the greater the occurrence of freezing of gait. Nineteen patients with Parkinsoǹs disease who experience freezing of gait (PD-FOG) walked through a doorway or into open space in complete darkness. The three doorway conditions included: (i) FRAME (DARK)--walking through the remembered door frame; (ii) FRAME--walking through the door with the door frame illuminated; (iii) FRAME+BODY--walking through the door (both the door and the limbs illuminated). Additionally, two conditions of walking away from the doorway included: (iv) NO FRAME (DARK)--walking into open space; (v) NO FRAME+BODY--walking into open space with the limbs illuminated, to evaluate whether perception (or fear) of the doorway might account for FOG behaviour. Key outcome measures included: the number of freezing of gait episodes recorded, total duration of freezing of gait, and the percentage of time spent frozen. Significantly more freezing of gait episodes occurred when participants walked toward the doorway in complete darkness compared to walking into open space (p<0.05). Similar to previous studies, velocity (p<0.001) and step length (p<0.0001) significantly decreased when walking through the door in complete darkness, compared to all other conditions. Significant increases in step width variability were also identified but only when walking into open space (p<0.005). These results support the notion that sensory deficits may have a profound impact on freezing of gait that need to be carefully considered.Kaylena A Ehgoetz MartensFrederico Pieruccini-FariaQuincy J AlmeidaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e62602 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaylena A Ehgoetz Martens Frederico Pieruccini-Faria Quincy J Almeida Could sensory mechanisms be a core factor that underlies freezing of gait in Parkinson's disease?
description	The main objective of this study was to determine how manipulating the amount of sensory information available about the body and surrounding environment influenced freezing of gait (FOG), while walking through a doorway. It was hypothesized that the more limited the sensory information, the greater the occurrence of freezing of gait. Nineteen patients with Parkinsoǹs disease who experience freezing of gait (PD-FOG) walked through a doorway or into open space in complete darkness. The three doorway conditions included: (i) FRAME (DARK)--walking through the remembered door frame; (ii) FRAME--walking through the door with the door frame illuminated; (iii) FRAME+BODY--walking through the door (both the door and the limbs illuminated). Additionally, two conditions of walking away from the doorway included: (iv) NO FRAME (DARK)--walking into open space; (v) NO FRAME+BODY--walking into open space with the limbs illuminated, to evaluate whether perception (or fear) of the doorway might account for FOG behaviour. Key outcome measures included: the number of freezing of gait episodes recorded, total duration of freezing of gait, and the percentage of time spent frozen. Significantly more freezing of gait episodes occurred when participants walked toward the doorway in complete darkness compared to walking into open space (p<0.05). Similar to previous studies, velocity (p<0.001) and step length (p<0.0001) significantly decreased when walking through the door in complete darkness, compared to all other conditions. Significant increases in step width variability were also identified but only when walking into open space (p<0.005). These results support the notion that sensory deficits may have a profound impact on freezing of gait that need to be carefully considered.
format	article
author	Kaylena A Ehgoetz Martens Frederico Pieruccini-Faria Quincy J Almeida
author_facet	Kaylena A Ehgoetz Martens Frederico Pieruccini-Faria Quincy J Almeida
author_sort	Kaylena A Ehgoetz Martens
title	Could sensory mechanisms be a core factor that underlies freezing of gait in Parkinson's disease?
title_short	Could sensory mechanisms be a core factor that underlies freezing of gait in Parkinson's disease?
title_full	Could sensory mechanisms be a core factor that underlies freezing of gait in Parkinson's disease?
title_fullStr	Could sensory mechanisms be a core factor that underlies freezing of gait in Parkinson's disease?
title_full_unstemmed	Could sensory mechanisms be a core factor that underlies freezing of gait in Parkinson's disease?
title_sort	could sensory mechanisms be a core factor that underlies freezing of gait in parkinson's disease?
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/28229962a560402595866380ec9d18a5
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Could sensory mechanisms be a core factor that underlies freezing of gait in Parkinson's disease?

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