Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor

Objectives: To analyze the clinical and imaging features of acute ischemic stroke (AIS) related to gastrointestinal malignant tumor, and to explore the prognostic factors.Methods: Clinical data of consecutive patients with gastrointestinal malignant tumor complicated with AIS admitted to the Departm...

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Autores principales:	Yating Liu, Xin Li, Feixue Song, Xin Yan, Zhijian Han, Futian Tang, Yumin Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gastrointestinal malignant tumor acute ischemic stroke D-dimer (DD) TAT prognosis Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/28292850cd5a4fea86e04fd84e9fde8a
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spelling	oai:doaj.org-article:28292850cd5a4fea86e04fd84e9fde8a2021-12-01T01:11:07ZClinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor1664-229510.3389/fneur.2021.777483https://doaj.org/article/28292850cd5a4fea86e04fd84e9fde8a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.777483/fullhttps://doaj.org/toc/1664-2295Objectives: To analyze the clinical and imaging features of acute ischemic stroke (AIS) related to gastrointestinal malignant tumor, and to explore the prognostic factors.Methods: Clinical data of consecutive patients with gastrointestinal malignant tumor complicated with AIS admitted to the Department of Neurology and Oncology in Lanzhou University Second Hospital from April 2015 to April 2019 were retrospectively analyzed. Patients were divided into good prognosis (mRS 0–2) and poor prognosis (mRS > 2) based on a 90-day mRS score after discharge. The multivariate logistic regression model was used to analyze the prognostic factors.Results: A total of 68 patients were enrolled with an average age of 61.78 ± 6.65 years, including 49 men (72.06%). There were 18 patients in the good prognosis group and 50 patients in the poor prognosis group. The univariate analysis showed that Hcy, D-dimer, thrombin–antithrombin complex (TAT), and three territory sign in magnetic resonance imaging (MRI) were the risk factors for poor prognosis. Multivariate analysis showed that increased D-dimer (OR 4.497, 95% CI 1.014–19.938) and TAT levels (OR 4.294, 95% CI 1.654–11.149) were independent risk factors for the prognosis in such patients.Conclusion: Image of patients with gastrointestinal malignant tumor-related AIS is characterized by three territory sign (multiple lesions in different vascular supply areas). Increased TAT and D-dimer levels are independent prognostic risk factors. TAT is more sensitive to predict prognosis than D-dimer.Yating LiuYating LiuXin LiFeixue SongXin YanZhijian HanFutian TangYumin LiFrontiers Media S.A.articlegastrointestinal malignant tumoracute ischemic strokeD-dimer (DD)TATprognosisNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastrointestinal malignant tumor acute ischemic stroke D-dimer (DD) TAT prognosis Neurology. Diseases of the nervous system RC346-429
spellingShingle	gastrointestinal malignant tumor acute ischemic stroke D-dimer (DD) TAT prognosis Neurology. Diseases of the nervous system RC346-429 Yating Liu Yating Liu Xin Li Feixue Song Xin Yan Zhijian Han Futian Tang Yumin Li Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor
description	Objectives: To analyze the clinical and imaging features of acute ischemic stroke (AIS) related to gastrointestinal malignant tumor, and to explore the prognostic factors.Methods: Clinical data of consecutive patients with gastrointestinal malignant tumor complicated with AIS admitted to the Department of Neurology and Oncology in Lanzhou University Second Hospital from April 2015 to April 2019 were retrospectively analyzed. Patients were divided into good prognosis (mRS 0–2) and poor prognosis (mRS > 2) based on a 90-day mRS score after discharge. The multivariate logistic regression model was used to analyze the prognostic factors.Results: A total of 68 patients were enrolled with an average age of 61.78 ± 6.65 years, including 49 men (72.06%). There were 18 patients in the good prognosis group and 50 patients in the poor prognosis group. The univariate analysis showed that Hcy, D-dimer, thrombin–antithrombin complex (TAT), and three territory sign in magnetic resonance imaging (MRI) were the risk factors for poor prognosis. Multivariate analysis showed that increased D-dimer (OR 4.497, 95% CI 1.014–19.938) and TAT levels (OR 4.294, 95% CI 1.654–11.149) were independent risk factors for the prognosis in such patients.Conclusion: Image of patients with gastrointestinal malignant tumor-related AIS is characterized by three territory sign (multiple lesions in different vascular supply areas). Increased TAT and D-dimer levels are independent prognostic risk factors. TAT is more sensitive to predict prognosis than D-dimer.
format	article
author	Yating Liu Yating Liu Xin Li Feixue Song Xin Yan Zhijian Han Futian Tang Yumin Li
author_facet	Yating Liu Yating Liu Xin Li Feixue Song Xin Yan Zhijian Han Futian Tang Yumin Li
author_sort	Yating Liu
title	Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor
title_short	Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor
title_full	Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor
title_fullStr	Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor
title_full_unstemmed	Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor
title_sort	clinical features and prognostic factors of acute ischemic stroke related to malignant gastrointestinal tumor
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/28292850cd5a4fea86e04fd84e9fde8a
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Clinical Features and Prognostic Factors of Acute Ischemic Stroke Related to Malignant Gastrointestinal Tumor

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