Longitudinal Study of the Association between General Anesthesia and Increased Risk of Developing Dementia

The association between exposure to general anesthesia (GA) and the risk of dementia is still undetermined. To investigate a possible link to the development of dementia in older people who have undergone GA, we analyzed nationwide representative cohort sample data from the Korean National Health In...

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Autores principales:	Jong-Hee Sohn, Jae Jun Lee, Sang-Hwa Lee, Chulho Kim, Hyunjae Yu, Young-Suk Kwon, Dong-Kyu Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	general anesthesia dementia Alzheimer’s disease vascular dementia Medicine R
Acceso en línea:	https://doaj.org/article/282d3edf9118483c8d63dd2d9931f470
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spelling	oai:doaj.org-article:282d3edf9118483c8d63dd2d9931f4702021-11-25T18:08:04ZLongitudinal Study of the Association between General Anesthesia and Increased Risk of Developing Dementia10.3390/jpm111112152075-4426https://doaj.org/article/282d3edf9118483c8d63dd2d9931f4702021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1215https://doaj.org/toc/2075-4426The association between exposure to general anesthesia (GA) and the risk of dementia is still undetermined. To investigate a possible link to the development of dementia in older people who have undergone GA, we analyzed nationwide representative cohort sample data from the Korean National Health Insurance Service. The study cohort comprised patients over 55 years of age who had undergone GA between January 2003 and December 2004 and consisted of 3100 patients who had undergone GA and 12,400 comparison subjects who had not received anesthesia. After the nine-year follow-up period, we found the overall incidence of dementia was higher in the patients who had undergone GA than in the comparison group (10.5 vs. 8.8 per 1000 person-years), with the risk being greater for women (adjusted HR of 1.44; 95% CI, 1.19–1.75) and those with comorbidities (adjusted HR of 1.39; 95% CI, 1.18–1.64). Patients who underwent GA showed higher risks for Alzheimer’s disease and vascular dementia (adjusted HR of 1.52; 95% CI, 1.27–1.82 and 1.64; 95% CI, 1.15–2.33, respectively). This longitudinal study using a sample cohort based on a nationwide population sample demonstrated a significant positive association between GA and dementia, including Alzheimer’s disease and vascular dementia.Jong-Hee SohnJae Jun LeeSang-Hwa LeeChulho KimHyunjae YuYoung-Suk KwonDong-Kyu KimMDPI AGarticlegeneral anesthesiadementiaAlzheimer’s diseasevascular dementiaMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1215, p 1215 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	general anesthesia dementia Alzheimer’s disease vascular dementia Medicine R
spellingShingle	general anesthesia dementia Alzheimer’s disease vascular dementia Medicine R Jong-Hee Sohn Jae Jun Lee Sang-Hwa Lee Chulho Kim Hyunjae Yu Young-Suk Kwon Dong-Kyu Kim Longitudinal Study of the Association between General Anesthesia and Increased Risk of Developing Dementia
description	The association between exposure to general anesthesia (GA) and the risk of dementia is still undetermined. To investigate a possible link to the development of dementia in older people who have undergone GA, we analyzed nationwide representative cohort sample data from the Korean National Health Insurance Service. The study cohort comprised patients over 55 years of age who had undergone GA between January 2003 and December 2004 and consisted of 3100 patients who had undergone GA and 12,400 comparison subjects who had not received anesthesia. After the nine-year follow-up period, we found the overall incidence of dementia was higher in the patients who had undergone GA than in the comparison group (10.5 vs. 8.8 per 1000 person-years), with the risk being greater for women (adjusted HR of 1.44; 95% CI, 1.19–1.75) and those with comorbidities (adjusted HR of 1.39; 95% CI, 1.18–1.64). Patients who underwent GA showed higher risks for Alzheimer’s disease and vascular dementia (adjusted HR of 1.52; 95% CI, 1.27–1.82 and 1.64; 95% CI, 1.15–2.33, respectively). This longitudinal study using a sample cohort based on a nationwide population sample demonstrated a significant positive association between GA and dementia, including Alzheimer’s disease and vascular dementia.
format	article
author	Jong-Hee Sohn Jae Jun Lee Sang-Hwa Lee Chulho Kim Hyunjae Yu Young-Suk Kwon Dong-Kyu Kim
author_facet	Jong-Hee Sohn Jae Jun Lee Sang-Hwa Lee Chulho Kim Hyunjae Yu Young-Suk Kwon Dong-Kyu Kim
author_sort	Jong-Hee Sohn
title	Longitudinal Study of the Association between General Anesthesia and Increased Risk of Developing Dementia
title_short	Longitudinal Study of the Association between General Anesthesia and Increased Risk of Developing Dementia
title_full	Longitudinal Study of the Association between General Anesthesia and Increased Risk of Developing Dementia
title_fullStr	Longitudinal Study of the Association between General Anesthesia and Increased Risk of Developing Dementia
title_full_unstemmed	Longitudinal Study of the Association between General Anesthesia and Increased Risk of Developing Dementia
title_sort	longitudinal study of the association between general anesthesia and increased risk of developing dementia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/282d3edf9118483c8d63dd2d9931f470
work_keys_str_mv	AT jongheesohn longitudinalstudyoftheassociationbetweengeneralanesthesiaandincreasedriskofdevelopingdementia AT jaejunlee longitudinalstudyoftheassociationbetweengeneralanesthesiaandincreasedriskofdevelopingdementia AT sanghwalee longitudinalstudyoftheassociationbetweengeneralanesthesiaandincreasedriskofdevelopingdementia AT chulhokim longitudinalstudyoftheassociationbetweengeneralanesthesiaandincreasedriskofdevelopingdementia AT hyunjaeyu longitudinalstudyoftheassociationbetweengeneralanesthesiaandincreasedriskofdevelopingdementia AT youngsukkwon longitudinalstudyoftheassociationbetweengeneralanesthesiaandincreasedriskofdevelopingdementia AT dongkyukim longitudinalstudyoftheassociationbetweengeneralanesthesiaandincreasedriskofdevelopingdementia
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Longitudinal Study of the Association between General Anesthesia and Increased Risk of Developing Dementia

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