CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma

Oesophageal squamous cell carcinoma often develop resistance to EGFR tyrosine kinase inhibitors. Here, the authors demonstrate that inhibition of cell cycle regulators CDK4/6 or MAPK blockade enhances the efficacy of EGFR inhibitors for these tumours in mice.

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Autores principales:	Jin Zhou, Zhong Wu, Gabrielle Wong, Eirini Pectasides, Ankur Nagaraja, Matthew Stachler, Haikuo Zhang, Ting Chen, Haisheng Zhang, Jie Bin Liu, Xinsen Xu, Ewa Sicinska, Francisco Sanchez-Vega, Anil K. Rustgi, J. Alan Diehl, Kwok-Kin Wong, Adam J. Bass
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/282f92eea86c444d9bab4d8683fb7b94
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spelling	oai:doaj.org-article:282f92eea86c444d9bab4d8683fb7b942021-12-02T15:38:35ZCDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma10.1038/ncomms138972041-1723https://doaj.org/article/282f92eea86c444d9bab4d8683fb7b942017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13897https://doaj.org/toc/2041-1723Oesophageal squamous cell carcinoma often develop resistance to EGFR tyrosine kinase inhibitors. Here, the authors demonstrate that inhibition of cell cycle regulators CDK4/6 or MAPK blockade enhances the efficacy of EGFR inhibitors for these tumours in mice.Jin ZhouZhong WuGabrielle WongEirini PectasidesAnkur NagarajaMatthew StachlerHaikuo ZhangTing ChenHaisheng ZhangJie Bin LiuXinsen XuEwa SicinskaFrancisco Sanchez-VegaAnil K. RustgiJ. Alan DiehlKwok-Kin WongAdam J. BassNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jin Zhou Zhong Wu Gabrielle Wong Eirini Pectasides Ankur Nagaraja Matthew Stachler Haikuo Zhang Ting Chen Haisheng Zhang Jie Bin Liu Xinsen Xu Ewa Sicinska Francisco Sanchez-Vega Anil K. Rustgi J. Alan Diehl Kwok-Kin Wong Adam J. Bass CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma
description	Oesophageal squamous cell carcinoma often develop resistance to EGFR tyrosine kinase inhibitors. Here, the authors demonstrate that inhibition of cell cycle regulators CDK4/6 or MAPK blockade enhances the efficacy of EGFR inhibitors for these tumours in mice.
format	article
author	Jin Zhou Zhong Wu Gabrielle Wong Eirini Pectasides Ankur Nagaraja Matthew Stachler Haikuo Zhang Ting Chen Haisheng Zhang Jie Bin Liu Xinsen Xu Ewa Sicinska Francisco Sanchez-Vega Anil K. Rustgi J. Alan Diehl Kwok-Kin Wong Adam J. Bass
author_facet	Jin Zhou Zhong Wu Gabrielle Wong Eirini Pectasides Ankur Nagaraja Matthew Stachler Haikuo Zhang Ting Chen Haisheng Zhang Jie Bin Liu Xinsen Xu Ewa Sicinska Francisco Sanchez-Vega Anil K. Rustgi J. Alan Diehl Kwok-Kin Wong Adam J. Bass
author_sort	Jin Zhou
title	CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma
title_short	CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma
title_full	CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma
title_fullStr	CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma
title_full_unstemmed	CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma
title_sort	cdk4/6 or mapk blockade enhances efficacy of egfr inhibition in oesophageal squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/282f92eea86c444d9bab4d8683fb7b94
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CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma

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