To Balloon or Not to Balloon? The Effects of an Intra-Aortic Balloon-Pump on Coronary Artery Flow during Extracorporeal Circulation Simulating Normal and Low Cardiac Output Syndromes

ECMO is the most frequently used mechanical support for patients suffering from low cardiac output syndrome. Combining IABP with ECMO is believed to increase coronary artery blood flow, decrease high afterload, and restore systemic pulsatile flow conditions. This study evaluates that combined effect...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Philippe Reymond, Karim Bendjelid, Raphaël Giraud, Gérald Richard, Nicolas Murith, Mustafa Cikirikcioglu, Christoph Huber
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ECMO IABP in vitro mock-up circuit low cardiac output syndrome coronary blood flow Medicine R
Acceso en línea:	https://doaj.org/article/283139532f374ff1818de0ec95f31eaa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:283139532f374ff1818de0ec95f31eaa
record_format	dspace
spelling	oai:doaj.org-article:283139532f374ff1818de0ec95f31eaa2021-11-25T18:01:52ZTo Balloon or Not to Balloon? The Effects of an Intra-Aortic Balloon-Pump on Coronary Artery Flow during Extracorporeal Circulation Simulating Normal and Low Cardiac Output Syndromes10.3390/jcm102253332077-0383https://doaj.org/article/283139532f374ff1818de0ec95f31eaa2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5333https://doaj.org/toc/2077-0383ECMO is the most frequently used mechanical support for patients suffering from low cardiac output syndrome. Combining IABP with ECMO is believed to increase coronary artery blood flow, decrease high afterload, and restore systemic pulsatile flow conditions. This study evaluates that combined effect on coronary artery flow during various load conditions using an in vitro circuit. In doing so, different clinical scenarios were simulated, such as normal cardiac output and moderate-to-severe heart failure. In the heart failure scenarios, we used peripheral ECMO support to compensate for the lowered cardiac output value and reach a default normal value. The increase in coronary blood flow using the combined IABP-ECMO setup was more noticeable in low heart rate conditions. At baseline, intermediate and severe LV failure levels, adding IABP increased coronary mean flow by 16%, 7.5%, and 3.4% (HR 60 bpm) and by 6%, 4.5%, and 2.5% (HR 100 bpm) respectively. Based on our in vitro study results, combining ECMO and IABP in a heart failure setup further improves coronary blood flow. This effect was more pronounced at a lower heart rate and decreased with heart failure, which might positively impact recovery from cardiac failure.Philippe ReymondKarim BendjelidRaphaël GiraudGérald RichardNicolas MurithMustafa CikirikciogluChristoph HuberMDPI AGarticleECMOIABPin vitro mock-up circuitlow cardiac output syndromecoronary blood flowMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5333, p 5333 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ECMO IABP in vitro mock-up circuit low cardiac output syndrome coronary blood flow Medicine R
spellingShingle	ECMO IABP in vitro mock-up circuit low cardiac output syndrome coronary blood flow Medicine R Philippe Reymond Karim Bendjelid Raphaël Giraud Gérald Richard Nicolas Murith Mustafa Cikirikcioglu Christoph Huber To Balloon or Not to Balloon? The Effects of an Intra-Aortic Balloon-Pump on Coronary Artery Flow during Extracorporeal Circulation Simulating Normal and Low Cardiac Output Syndromes
description	ECMO is the most frequently used mechanical support for patients suffering from low cardiac output syndrome. Combining IABP with ECMO is believed to increase coronary artery blood flow, decrease high afterload, and restore systemic pulsatile flow conditions. This study evaluates that combined effect on coronary artery flow during various load conditions using an in vitro circuit. In doing so, different clinical scenarios were simulated, such as normal cardiac output and moderate-to-severe heart failure. In the heart failure scenarios, we used peripheral ECMO support to compensate for the lowered cardiac output value and reach a default normal value. The increase in coronary blood flow using the combined IABP-ECMO setup was more noticeable in low heart rate conditions. At baseline, intermediate and severe LV failure levels, adding IABP increased coronary mean flow by 16%, 7.5%, and 3.4% (HR 60 bpm) and by 6%, 4.5%, and 2.5% (HR 100 bpm) respectively. Based on our in vitro study results, combining ECMO and IABP in a heart failure setup further improves coronary blood flow. This effect was more pronounced at a lower heart rate and decreased with heart failure, which might positively impact recovery from cardiac failure.
format	article
author	Philippe Reymond Karim Bendjelid Raphaël Giraud Gérald Richard Nicolas Murith Mustafa Cikirikcioglu Christoph Huber
author_facet	Philippe Reymond Karim Bendjelid Raphaël Giraud Gérald Richard Nicolas Murith Mustafa Cikirikcioglu Christoph Huber
author_sort	Philippe Reymond
title	To Balloon or Not to Balloon? The Effects of an Intra-Aortic Balloon-Pump on Coronary Artery Flow during Extracorporeal Circulation Simulating Normal and Low Cardiac Output Syndromes
title_short	To Balloon or Not to Balloon? The Effects of an Intra-Aortic Balloon-Pump on Coronary Artery Flow during Extracorporeal Circulation Simulating Normal and Low Cardiac Output Syndromes
title_full	To Balloon or Not to Balloon? The Effects of an Intra-Aortic Balloon-Pump on Coronary Artery Flow during Extracorporeal Circulation Simulating Normal and Low Cardiac Output Syndromes
title_fullStr	To Balloon or Not to Balloon? The Effects of an Intra-Aortic Balloon-Pump on Coronary Artery Flow during Extracorporeal Circulation Simulating Normal and Low Cardiac Output Syndromes
title_full_unstemmed	To Balloon or Not to Balloon? The Effects of an Intra-Aortic Balloon-Pump on Coronary Artery Flow during Extracorporeal Circulation Simulating Normal and Low Cardiac Output Syndromes
title_sort	to balloon or not to balloon? the effects of an intra-aortic balloon-pump on coronary artery flow during extracorporeal circulation simulating normal and low cardiac output syndromes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/283139532f374ff1818de0ec95f31eaa
work_keys_str_mv	AT philippereymond toballoonornottoballoontheeffectsofanintraaorticballoonpumponcoronaryarteryflowduringextracorporealcirculationsimulatingnormalandlowcardiacoutputsyndromes AT karimbendjelid toballoonornottoballoontheeffectsofanintraaorticballoonpumponcoronaryarteryflowduringextracorporealcirculationsimulatingnormalandlowcardiacoutputsyndromes AT raphaelgiraud toballoonornottoballoontheeffectsofanintraaorticballoonpumponcoronaryarteryflowduringextracorporealcirculationsimulatingnormalandlowcardiacoutputsyndromes AT geraldrichard toballoonornottoballoontheeffectsofanintraaorticballoonpumponcoronaryarteryflowduringextracorporealcirculationsimulatingnormalandlowcardiacoutputsyndromes AT nicolasmurith toballoonornottoballoontheeffectsofanintraaorticballoonpumponcoronaryarteryflowduringextracorporealcirculationsimulatingnormalandlowcardiacoutputsyndromes AT mustafacikirikcioglu toballoonornottoballoontheeffectsofanintraaorticballoonpumponcoronaryarteryflowduringextracorporealcirculationsimulatingnormalandlowcardiacoutputsyndromes AT christophhuber toballoonornottoballoontheeffectsofanintraaorticballoonpumponcoronaryarteryflowduringextracorporealcirculationsimulatingnormalandlowcardiacoutputsyndromes
_version_	1718411668341391360

To Balloon or Not to Balloon? The Effects of an Intra-Aortic Balloon-Pump on Coronary Artery Flow during Extracorporeal Circulation Simulating Normal and Low Cardiac Output Syndromes

Ejemplares similares