Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity

Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity

Abstract Lectins, carbohydrate-binding proteins, have been regarded as potential antiviral agents, as some can bind glycans on viral surface glycoproteins and inactivate their functions. However, clinical development of lectins has been stalled by the mitogenicity of many of these proteins, which is...

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Autores principales: Evelyn M. Covés-Datson, Steven R. King, Maureen Legendre, Michael D. Swanson, Auroni Gupta, Sandra Claes, Jennifer L. Meagher, Arnaud Boonen, Lihong Zhang, Birte Kalveram, Zoe Raglow, Alexander N. Freiberg, Mark Prichard, Jeanne A. Stuckey, Dominique Schols, David M. Markovitz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/283392a3b205412094e2427caa1508b6
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