Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels

Abstract Although bats are natural reservoir hosts for numerous zoonotic viruses, little is known about the long-term dynamics of the host immune response following infection and how these viruses are maintained in nature. The Egyptian rousette bat (ERB) is a known reservoir host for Marburg virus (...

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Autores principales:	Amy J. Schuh, Brian R. Amman, Tara K. Sealy, Jessica R. Spengler, Stuart T. Nichol, Jonathan S. Towner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/28382aeb8cd74900bcbb1cd8c053b081
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spelling	oai:doaj.org-article:28382aeb8cd74900bcbb1cd8c053b0812021-12-02T11:41:23ZEgyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels10.1038/s41598-017-07824-22045-2322https://doaj.org/article/28382aeb8cd74900bcbb1cd8c053b0812017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07824-2https://doaj.org/toc/2045-2322Abstract Although bats are natural reservoir hosts for numerous zoonotic viruses, little is known about the long-term dynamics of the host immune response following infection and how these viruses are maintained in nature. The Egyptian rousette bat (ERB) is a known reservoir host for Marburg virus (MARV). Following infection of ERBs with MARV, virus-specific IgG antibodies are induced but rapidly wane and by 3 months post-infection the bats are seronegative. To determine whether reinfection of ERBs plays a role in MARV maintenance, we challenge groups of ERBs that were “naturally” or experimentally infected with MARV 17–24 months prior. No bats in either group exhibit evidence of MARV replication or shedding and all bats develop virus-specific secondary immune responses. This study demonstrates that infection of ERBs with MARV induces long-term protective immunity against reinfection and indicates that other factors, such as host population dynamics, drive MARV maintenance in nature.Amy J. SchuhBrian R. AmmanTara K. SealyJessica R. SpenglerStuart T. NicholJonathan S. TownerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amy J. Schuh Brian R. Amman Tara K. Sealy Jessica R. Spengler Stuart T. Nichol Jonathan S. Towner Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels
description	Abstract Although bats are natural reservoir hosts for numerous zoonotic viruses, little is known about the long-term dynamics of the host immune response following infection and how these viruses are maintained in nature. The Egyptian rousette bat (ERB) is a known reservoir host for Marburg virus (MARV). Following infection of ERBs with MARV, virus-specific IgG antibodies are induced but rapidly wane and by 3 months post-infection the bats are seronegative. To determine whether reinfection of ERBs plays a role in MARV maintenance, we challenge groups of ERBs that were “naturally” or experimentally infected with MARV 17–24 months prior. No bats in either group exhibit evidence of MARV replication or shedding and all bats develop virus-specific secondary immune responses. This study demonstrates that infection of ERBs with MARV induces long-term protective immunity against reinfection and indicates that other factors, such as host population dynamics, drive MARV maintenance in nature.
format	article
author	Amy J. Schuh Brian R. Amman Tara K. Sealy Jessica R. Spengler Stuart T. Nichol Jonathan S. Towner
author_facet	Amy J. Schuh Brian R. Amman Tara K. Sealy Jessica R. Spengler Stuart T. Nichol Jonathan S. Towner
author_sort	Amy J. Schuh
title	Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels
title_short	Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels
title_full	Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels
title_fullStr	Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels
title_full_unstemmed	Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels
title_sort	egyptian rousette bats maintain long-term protective immunity against marburg virus infection despite diminished antibody levels
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/28382aeb8cd74900bcbb1cd8c053b081
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Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels

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