Parkinson's disease case ascertainment in a large prospective cohort.

<h4>Background</h4>In epidemiologic studies where physician-based case adjudication is not feasible, Parkinson's disease (PD) case ascertainment is often limited to self-reports which may not be accurate. We evaluated strategies to identify PD cases in the Agricultural Health Study...

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Autores principales:	Srishti Shrestha, Christine G Parks, Marie Richards-Barber, Honglei Chen, Dale P Sandler
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/283934eff4314641b03c1fb0fb0eb625
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spelling	oai:doaj.org-article:283934eff4314641b03c1fb0fb0eb6252021-12-02T20:11:17ZParkinson's disease case ascertainment in a large prospective cohort.1932-620310.1371/journal.pone.0251852https://doaj.org/article/283934eff4314641b03c1fb0fb0eb6252021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251852https://doaj.org/toc/1932-6203<h4>Background</h4>In epidemiologic studies where physician-based case adjudication is not feasible, Parkinson's disease (PD) case ascertainment is often limited to self-reports which may not be accurate. We evaluated strategies to identify PD cases in the Agricultural Health Study (AHS).<h4>Methods</h4>Doctor-diagnosed PD was self-reported on all cohort-wide surveys; potential cases were also identified from death certificates. Follow-up surveys asked about PD-related motor and non-motor symptoms. For PD confirmation, we collected additional diagnosis, symptom, and treatment data from 510 potential PD cases or their proxy (65% of those contacted) in a supplemental screener and obtained medical records for a subset (n = 65). We classified PD cases using established criteria and screener data.<h4>Results</h4>Of 510 potential PD cases, 75% were considered "probable" or "possible"; this proportion increased among participants diagnosed by a specialist (81.2%), taking PD medication (85.2%), or reporting ≥5 motor symptoms (86.8%) in a regular AHS survey. Of those with medical records, 93% (57 of 61) of probable or possible PD was confirmed. Never-smoking and non-motor and motor symptoms reported in prior AHS surveys were more common with probable/possible PD than unconfirmed PD.<h4>Conclusion</h4>In this retrospective PD case ascertainment effort, we found that PD self-report with information on motor symptoms or medications may be a reasonable alternative for identifying PD cases when physician exam is not feasible. Because of intervening mortality, screeners could not be obtained from about one-third of those contacted. Thus, findings warrant replication.Srishti ShresthaChristine G ParksMarie Richards-BarberHonglei ChenDale P SandlerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251852 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Srishti Shrestha Christine G Parks Marie Richards-Barber Honglei Chen Dale P Sandler Parkinson's disease case ascertainment in a large prospective cohort.
description	<h4>Background</h4>In epidemiologic studies where physician-based case adjudication is not feasible, Parkinson's disease (PD) case ascertainment is often limited to self-reports which may not be accurate. We evaluated strategies to identify PD cases in the Agricultural Health Study (AHS).<h4>Methods</h4>Doctor-diagnosed PD was self-reported on all cohort-wide surveys; potential cases were also identified from death certificates. Follow-up surveys asked about PD-related motor and non-motor symptoms. For PD confirmation, we collected additional diagnosis, symptom, and treatment data from 510 potential PD cases or their proxy (65% of those contacted) in a supplemental screener and obtained medical records for a subset (n = 65). We classified PD cases using established criteria and screener data.<h4>Results</h4>Of 510 potential PD cases, 75% were considered "probable" or "possible"; this proportion increased among participants diagnosed by a specialist (81.2%), taking PD medication (85.2%), or reporting ≥5 motor symptoms (86.8%) in a regular AHS survey. Of those with medical records, 93% (57 of 61) of probable or possible PD was confirmed. Never-smoking and non-motor and motor symptoms reported in prior AHS surveys were more common with probable/possible PD than unconfirmed PD.<h4>Conclusion</h4>In this retrospective PD case ascertainment effort, we found that PD self-report with information on motor symptoms or medications may be a reasonable alternative for identifying PD cases when physician exam is not feasible. Because of intervening mortality, screeners could not be obtained from about one-third of those contacted. Thus, findings warrant replication.
format	article
author	Srishti Shrestha Christine G Parks Marie Richards-Barber Honglei Chen Dale P Sandler
author_facet	Srishti Shrestha Christine G Parks Marie Richards-Barber Honglei Chen Dale P Sandler
author_sort	Srishti Shrestha
title	Parkinson's disease case ascertainment in a large prospective cohort.
title_short	Parkinson's disease case ascertainment in a large prospective cohort.
title_full	Parkinson's disease case ascertainment in a large prospective cohort.
title_fullStr	Parkinson's disease case ascertainment in a large prospective cohort.
title_full_unstemmed	Parkinson's disease case ascertainment in a large prospective cohort.
title_sort	parkinson's disease case ascertainment in a large prospective cohort.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/283934eff4314641b03c1fb0fb0eb625
work_keys_str_mv	AT srishtishrestha parkinsonsdiseasecaseascertainmentinalargeprospectivecohort AT christinegparks parkinsonsdiseasecaseascertainmentinalargeprospectivecohort AT marierichardsbarber parkinsonsdiseasecaseascertainmentinalargeprospectivecohort AT hongleichen parkinsonsdiseasecaseascertainmentinalargeprospectivecohort AT dalepsandler parkinsonsdiseasecaseascertainmentinalargeprospectivecohort
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Parkinson's disease case ascertainment in a large prospective cohort.

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