Natural killer cells: role in local tumor growth and metastasis

Natural killer cells: role in local tumor growth and metastasis

Inge Langers1,*, Virginie M Renoux1,*, Marc Thiry2, Philippe Delvenne1, Nathalie Jacobs1 1Laboratory of Experimental Pathology, GIGA-I3/GIGA-Cancer, University of Liège, 2Cellular and Tissular Biology, GIGA-Neurosciences, University of Liège, Liège, Belgi...

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Autores principales: Langers I, Renoux VM, Thiry M, Delvenne P, Jacobs N
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/283d85be7f96405a934e263e2e7ca2c7
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spelling oai:doaj.org-article:283d85be7f96405a934e263e2e7ca2c72021-12-02T07:15:35ZNatural killer cells: role in local tumor growth and metastasis1177-54751177-5491https://doaj.org/article/283d85be7f96405a934e263e2e7ca2c72012-04-01T00:00:00Zhttp://www.dovepress.com/natural-killer-cells-role-in-local-tumor-growth-and-metastasis-a9647https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Inge Langers1,*, Virginie M Renoux1,*, Marc Thiry2, Philippe Delvenne1, Nathalie Jacobs1 1Laboratory of Experimental Pathology, GIGA-I3/GIGA-Cancer, University of Liège, 2Cellular and Tissular Biology, GIGA-Neurosciences, University of Liège, Liège, Belgium*These authors contributed equally to this workAbstract: Historically, the name of natural killer (NK) cells came from their natural ability to kill tumor cells in vitro. From the 1970s to date, accumulating data highlighted the importance of NK cells in host immune response against cancer and in therapy-induced antitumor response. The recognition and the lysis of tumor cells by NK cells are regulated by a complex balance of inhibitory and activating signals. This review summarizes NK cell mechanisms to kill cancer cells, their role in host immune responses against tumor growth or metastasis, and their implications in antitumor immunotherapies via cytokines, antibodies, or in combination with other therapies. The regulatory role of NK cells in autoimmunity is also discussed.Keywords: natural killer, tumor, cytotoxicity, natural cytotoxicity receptorLangers IRenoux VMThiry MDelvenne PJacobs NDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2012, Iss default, Pp 73-82 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Langers I
Renoux VM
Thiry M
Delvenne P
Jacobs N
Natural killer cells: role in local tumor growth and metastasis
description Inge Langers1,*, Virginie M Renoux1,*, Marc Thiry2, Philippe Delvenne1, Nathalie Jacobs1 1Laboratory of Experimental Pathology, GIGA-I3/GIGA-Cancer, University of Liège, 2Cellular and Tissular Biology, GIGA-Neurosciences, University of Liège, Liège, Belgium*These authors contributed equally to this workAbstract: Historically, the name of natural killer (NK) cells came from their natural ability to kill tumor cells in vitro. From the 1970s to date, accumulating data highlighted the importance of NK cells in host immune response against cancer and in therapy-induced antitumor response. The recognition and the lysis of tumor cells by NK cells are regulated by a complex balance of inhibitory and activating signals. This review summarizes NK cell mechanisms to kill cancer cells, their role in host immune responses against tumor growth or metastasis, and their implications in antitumor immunotherapies via cytokines, antibodies, or in combination with other therapies. The regulatory role of NK cells in autoimmunity is also discussed.Keywords: natural killer, tumor, cytotoxicity, natural cytotoxicity receptor
format article
author Langers I
Renoux VM
Thiry M
Delvenne P
Jacobs N
author_facet Langers I
Renoux VM
Thiry M
Delvenne P
Jacobs N
author_sort Langers I
title Natural killer cells: role in local tumor growth and metastasis
title_short Natural killer cells: role in local tumor growth and metastasis
title_full Natural killer cells: role in local tumor growth and metastasis
title_fullStr Natural killer cells: role in local tumor growth and metastasis
title_full_unstemmed Natural killer cells: role in local tumor growth and metastasis
title_sort natural killer cells: role in local tumor growth and metastasis
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/283d85be7f96405a934e263e2e7ca2c7
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AT renouxvm naturalkillercellsroleinlocaltumorgrowthandmetastasis
AT thirym naturalkillercellsroleinlocaltumorgrowthandmetastasis
AT delvennep naturalkillercellsroleinlocaltumorgrowthandmetastasis
AT jacobsn naturalkillercellsroleinlocaltumorgrowthandmetastasis
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