Intensiometric biosensors visualize the activity of multiple small GTPases in vivo

FRET sensors hardly achieve visualization of spatiotemporal dynamics of protein activity in vivo. Here the authors present intensiometric small GTPase biosensors based on dimerization-dependent fluorescent proteins that enable monitoring of activity of small GTPases in the brains of behaving mice at...

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Autores principales:	Jihoon Kim, Sangkyu Lee, Kanghoon Jung, Won Chan Oh, Nury Kim, Seungkyu Son, YoungJu Jo, Hyung-Bae Kwon, Won Do Heo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/283e3420cefc4b53a0badf704ed46392
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spelling	oai:doaj.org-article:283e3420cefc4b53a0badf704ed463922021-12-02T15:35:32ZIntensiometric biosensors visualize the activity of multiple small GTPases in vivo10.1038/s41467-018-08217-32041-1723https://doaj.org/article/283e3420cefc4b53a0badf704ed463922019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08217-3https://doaj.org/toc/2041-1723FRET sensors hardly achieve visualization of spatiotemporal dynamics of protein activity in vivo. Here the authors present intensiometric small GTPase biosensors based on dimerization-dependent fluorescent proteins that enable monitoring of activity of small GTPases in the brains of behaving mice at a single spine resolution.Jihoon KimSangkyu LeeKanghoon JungWon Chan OhNury KimSeungkyu SonYoungJu JoHyung-Bae KwonWon Do HeoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jihoon Kim Sangkyu Lee Kanghoon Jung Won Chan Oh Nury Kim Seungkyu Son YoungJu Jo Hyung-Bae Kwon Won Do Heo Intensiometric biosensors visualize the activity of multiple small GTPases in vivo
description	FRET sensors hardly achieve visualization of spatiotemporal dynamics of protein activity in vivo. Here the authors present intensiometric small GTPase biosensors based on dimerization-dependent fluorescent proteins that enable monitoring of activity of small GTPases in the brains of behaving mice at a single spine resolution.
format	article
author	Jihoon Kim Sangkyu Lee Kanghoon Jung Won Chan Oh Nury Kim Seungkyu Son YoungJu Jo Hyung-Bae Kwon Won Do Heo
author_facet	Jihoon Kim Sangkyu Lee Kanghoon Jung Won Chan Oh Nury Kim Seungkyu Son YoungJu Jo Hyung-Bae Kwon Won Do Heo
author_sort	Jihoon Kim
title	Intensiometric biosensors visualize the activity of multiple small GTPases in vivo
title_short	Intensiometric biosensors visualize the activity of multiple small GTPases in vivo
title_full	Intensiometric biosensors visualize the activity of multiple small GTPases in vivo
title_fullStr	Intensiometric biosensors visualize the activity of multiple small GTPases in vivo
title_full_unstemmed	Intensiometric biosensors visualize the activity of multiple small GTPases in vivo
title_sort	intensiometric biosensors visualize the activity of multiple small gtpases in vivo
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/283e3420cefc4b53a0badf704ed46392
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Intensiometric biosensors visualize the activity of multiple small GTPases in vivo

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