Heme and hemoglobin utilization by Mycobacterium tuberculosis

Iron is essential for growth of Mycobacterium tuberculosis, but most of the iron in the human body is stored in heme within hemoglobin. Here, Mitra et al. identify two heme uptake mechanisms in M. tuberculosis, one dependent on the inner-membrane Dpp importer and the other dependent on host albumin.

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Autores principales:	Avishek Mitra, Ying-Hui Ko, Gino Cingolani, Michael Niederweis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/283f367554ff49d1baa027c6281b5a17
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id	oai:doaj.org-article:283f367554ff49d1baa027c6281b5a17
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spelling	oai:doaj.org-article:283f367554ff49d1baa027c6281b5a172021-12-02T15:35:11ZHeme and hemoglobin utilization by Mycobacterium tuberculosis10.1038/s41467-019-12109-52041-1723https://doaj.org/article/283f367554ff49d1baa027c6281b5a172019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12109-5https://doaj.org/toc/2041-1723Iron is essential for growth of Mycobacterium tuberculosis, but most of the iron in the human body is stored in heme within hemoglobin. Here, Mitra et al. identify two heme uptake mechanisms in M. tuberculosis, one dependent on the inner-membrane Dpp importer and the other dependent on host albumin.Avishek MitraYing-Hui KoGino CingolaniMichael NiederweisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Avishek Mitra Ying-Hui Ko Gino Cingolani Michael Niederweis Heme and hemoglobin utilization by Mycobacterium tuberculosis
description	Iron is essential for growth of Mycobacterium tuberculosis, but most of the iron in the human body is stored in heme within hemoglobin. Here, Mitra et al. identify two heme uptake mechanisms in M. tuberculosis, one dependent on the inner-membrane Dpp importer and the other dependent on host albumin.
format	article
author	Avishek Mitra Ying-Hui Ko Gino Cingolani Michael Niederweis
author_facet	Avishek Mitra Ying-Hui Ko Gino Cingolani Michael Niederweis
author_sort	Avishek Mitra
title	Heme and hemoglobin utilization by Mycobacterium tuberculosis
title_short	Heme and hemoglobin utilization by Mycobacterium tuberculosis
title_full	Heme and hemoglobin utilization by Mycobacterium tuberculosis
title_fullStr	Heme and hemoglobin utilization by Mycobacterium tuberculosis
title_full_unstemmed	Heme and hemoglobin utilization by Mycobacterium tuberculosis
title_sort	heme and hemoglobin utilization by mycobacterium tuberculosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/283f367554ff49d1baa027c6281b5a17
work_keys_str_mv	AT avishekmitra hemeandhemoglobinutilizationbymycobacteriumtuberculosis AT yinghuiko hemeandhemoglobinutilizationbymycobacteriumtuberculosis AT ginocingolani hemeandhemoglobinutilizationbymycobacteriumtuberculosis AT michaelniederweis hemeandhemoglobinutilizationbymycobacteriumtuberculosis
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Heme and hemoglobin utilization by Mycobacterium tuberculosis

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