Pilot Study to Evaluate Serum Soluble Mesothelin-Related Peptide (SMRP) as Marker for Clinical Monitoring of Pleural Mesothelioma (PM): Correlation with Modified RECIST Score

A soluble mesothelin-related peptide (SMRP) is the only FDA-approved biomarker for diagnosis of pleural mesothelioma (PM) and the most used for monitoring treatment. Radiological assessment of PM, based on modified RECIST (mRECIST) criteria, is challenging. This pilot study was designed to evaluate...

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Autores principales:	Federica Grosso, Matilde Mannucci, Francesca Ugo, Paola Ferro, Maurizio Cassinari, Antonella Vigani, Antonina Maria De Angelis, Sara Delfanti, Michela Lia, Roberto Guaschino, Stefano Barbero, Silvio Roncella, Ugo Giannoni, Marinella Bertolotti, Maria Pia Pistillo, Vincenzo Fontana
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mesothelioma mesothelin serum biomarkers modified RECIST longitudinal study Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/28405c6350474f358c3d863dfe112cdc
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spelling	oai:doaj.org-article:28405c6350474f358c3d863dfe112cdc2021-11-25T17:20:47ZPilot Study to Evaluate Serum Soluble Mesothelin-Related Peptide (SMRP) as Marker for Clinical Monitoring of Pleural Mesothelioma (PM): Correlation with Modified RECIST Score10.3390/diagnostics111120152075-4418https://doaj.org/article/28405c6350474f358c3d863dfe112cdc2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2015https://doaj.org/toc/2075-4418A soluble mesothelin-related peptide (SMRP) is the only FDA-approved biomarker for diagnosis of pleural mesothelioma (PM) and the most used for monitoring treatment. Radiological assessment of PM, based on modified RECIST (mRECIST) criteria, is challenging. This pilot study was designed to evaluate whether SMRP levels correlated over time with mRECIST score. Serial serum samples from PM patients were collected and SMRP levels were measured and compared with the mRECIST score obtained through centralized CT scans by blinded review. The within-patient SMRP-mRECIST relationship over time was estimated through a normal random-effects regression approach applied to the log-transformed mRECIST score. Overall, 58 PM patients were included (46 males and 12 females) with a median age at diagnosis of 67 years (min–max = 48–79), 44 (76%) with epithelioid and 14 (24%) with non-epithelioid histology. The total number of SMRP measurements and CT scans considered for analysis was 183. There was a statistically significant correlation between SMRP and mRECIST score in the 2 cohorts considered both separately and jointly. These results, although exploratory, suggest that SMRP measurement might be considered as an adjunct to monitor PM patients in order to delay CT scans time interval, thus warranting further investigation.Federica GrossoMatilde MannucciFrancesca UgoPaola FerroMaurizio CassinariAntonella ViganiAntonina Maria De AngelisSara DelfantiMichela LiaRoberto GuaschinoStefano BarberoSilvio RoncellaUgo GiannoniMarinella BertolottiMaria Pia PistilloVincenzo FontanaMDPI AGarticlemesotheliomamesothelinserum biomarkersmodified RECISTlongitudinal studyMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2015, p 2015 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesothelioma mesothelin serum biomarkers modified RECIST longitudinal study Medicine (General) R5-920
spellingShingle	mesothelioma mesothelin serum biomarkers modified RECIST longitudinal study Medicine (General) R5-920 Federica Grosso Matilde Mannucci Francesca Ugo Paola Ferro Maurizio Cassinari Antonella Vigani Antonina Maria De Angelis Sara Delfanti Michela Lia Roberto Guaschino Stefano Barbero Silvio Roncella Ugo Giannoni Marinella Bertolotti Maria Pia Pistillo Vincenzo Fontana Pilot Study to Evaluate Serum Soluble Mesothelin-Related Peptide (SMRP) as Marker for Clinical Monitoring of Pleural Mesothelioma (PM): Correlation with Modified RECIST Score
description	A soluble mesothelin-related peptide (SMRP) is the only FDA-approved biomarker for diagnosis of pleural mesothelioma (PM) and the most used for monitoring treatment. Radiological assessment of PM, based on modified RECIST (mRECIST) criteria, is challenging. This pilot study was designed to evaluate whether SMRP levels correlated over time with mRECIST score. Serial serum samples from PM patients were collected and SMRP levels were measured and compared with the mRECIST score obtained through centralized CT scans by blinded review. The within-patient SMRP-mRECIST relationship over time was estimated through a normal random-effects regression approach applied to the log-transformed mRECIST score. Overall, 58 PM patients were included (46 males and 12 females) with a median age at diagnosis of 67 years (min–max = 48–79), 44 (76%) with epithelioid and 14 (24%) with non-epithelioid histology. The total number of SMRP measurements and CT scans considered for analysis was 183. There was a statistically significant correlation between SMRP and mRECIST score in the 2 cohorts considered both separately and jointly. These results, although exploratory, suggest that SMRP measurement might be considered as an adjunct to monitor PM patients in order to delay CT scans time interval, thus warranting further investigation.
format	article
author	Federica Grosso Matilde Mannucci Francesca Ugo Paola Ferro Maurizio Cassinari Antonella Vigani Antonina Maria De Angelis Sara Delfanti Michela Lia Roberto Guaschino Stefano Barbero Silvio Roncella Ugo Giannoni Marinella Bertolotti Maria Pia Pistillo Vincenzo Fontana
author_facet	Federica Grosso Matilde Mannucci Francesca Ugo Paola Ferro Maurizio Cassinari Antonella Vigani Antonina Maria De Angelis Sara Delfanti Michela Lia Roberto Guaschino Stefano Barbero Silvio Roncella Ugo Giannoni Marinella Bertolotti Maria Pia Pistillo Vincenzo Fontana
author_sort	Federica Grosso
title	Pilot Study to Evaluate Serum Soluble Mesothelin-Related Peptide (SMRP) as Marker for Clinical Monitoring of Pleural Mesothelioma (PM): Correlation with Modified RECIST Score
title_short	Pilot Study to Evaluate Serum Soluble Mesothelin-Related Peptide (SMRP) as Marker for Clinical Monitoring of Pleural Mesothelioma (PM): Correlation with Modified RECIST Score
title_full	Pilot Study to Evaluate Serum Soluble Mesothelin-Related Peptide (SMRP) as Marker for Clinical Monitoring of Pleural Mesothelioma (PM): Correlation with Modified RECIST Score
title_fullStr	Pilot Study to Evaluate Serum Soluble Mesothelin-Related Peptide (SMRP) as Marker for Clinical Monitoring of Pleural Mesothelioma (PM): Correlation with Modified RECIST Score
title_full_unstemmed	Pilot Study to Evaluate Serum Soluble Mesothelin-Related Peptide (SMRP) as Marker for Clinical Monitoring of Pleural Mesothelioma (PM): Correlation with Modified RECIST Score
title_sort	pilot study to evaluate serum soluble mesothelin-related peptide (smrp) as marker for clinical monitoring of pleural mesothelioma (pm): correlation with modified recist score
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/28405c6350474f358c3d863dfe112cdc
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Pilot Study to Evaluate Serum Soluble Mesothelin-Related Peptide (SMRP) as Marker for Clinical Monitoring of Pleural Mesothelioma (PM): Correlation with Modified RECIST Score

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