Modeling of external self-excitation and force generation on magnetic nanoparticles inside vitreous cavity

The purpose of this manuscript was to design a better method for recovery from rhegmatogenous retinal detachment (RRD) surgery. We attempted to achieve this by designing a helmet that can manipulate intraocular magnetic nanoparticles (MNPs) and create a magnetic tamponade, eliminating the need for p...

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Autores principales:	Evan Parker, Chandler S. Mitchell, Joshua P Smith, Evan Carr, Rasul Akbari, Afshin Izadian, Amir R Hajrasouliha
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	magnetic nanoparticle helmet retinal detachment Biotechnology TP248.13-248.65 Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/284398937bfc4cd79fe141e40d848bdc
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id	oai:doaj.org-article:284398937bfc4cd79fe141e40d848bdc
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spelling	oai:doaj.org-article:284398937bfc4cd79fe141e40d848bdc2021-11-29T06:12:21ZModeling of external self-excitation and force generation on magnetic nanoparticles inside vitreous cavity10.3934/mbe.20214611551-0018https://doaj.org/article/284398937bfc4cd79fe141e40d848bdc2021-10-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021461?viewType=HTMLhttps://doaj.org/toc/1551-0018The purpose of this manuscript was to design a better method for recovery from rhegmatogenous retinal detachment (RRD) surgery. We attempted to achieve this by designing a helmet that can manipulate intraocular magnetic nanoparticles (MNPs) and create a magnetic tamponade, eliminating the need for postoperative head positioning. A simulated analysis was developed to predict the pattern of magnetic force applied to the magnetic nanoparticles by external magnetic field. No participants were involved in this study. Instead, magnetic flux and force data for three different helmet designs were collected using virtual simulation tools. A prototype helmet was then constructed and magnetic flux and force data were recorded and compared to virtual data. For both virtual and physical scenarios, magnitude and direction of the resulting forces were compared to determine which design created the controlled direction and strongest forces into the back of the eye. Of the three virtual designs, both designs containing a visor had greater force magnitude than magnet alone. Between both designs with visors, the visor with bends resulted in forces more directed at the back of the eye. The physical prototype helmet shared similar measurements to virtual simulation with minimal percent error (Average = 5.47%, Standard deviation = 0.03). Of the three designs, the visor with bends generated stronger forces directed at the back of the eye, which is most appropriate for creating a tamponade on the retina. We believe that this design has shown promising capability for manipulating intraocular MNPs for the purpose of creating a tamponade for RRD.Evan Parker Chandler S. MitchellJoshua P SmithEvan CarrRasul AkbariAfshin IzadianAmir R HajrasoulihaAIMS PressarticlemagneticnanoparticlehelmetretinaldetachmentBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 6, Pp 9381-9393 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic nanoparticle helmet retinal detachment Biotechnology TP248.13-248.65 Mathematics QA1-939
spellingShingle	magnetic nanoparticle helmet retinal detachment Biotechnology TP248.13-248.65 Mathematics QA1-939 Evan Parker Chandler S. Mitchell Joshua P Smith Evan Carr Rasul Akbari Afshin Izadian Amir R Hajrasouliha Modeling of external self-excitation and force generation on magnetic nanoparticles inside vitreous cavity
description	The purpose of this manuscript was to design a better method for recovery from rhegmatogenous retinal detachment (RRD) surgery. We attempted to achieve this by designing a helmet that can manipulate intraocular magnetic nanoparticles (MNPs) and create a magnetic tamponade, eliminating the need for postoperative head positioning. A simulated analysis was developed to predict the pattern of magnetic force applied to the magnetic nanoparticles by external magnetic field. No participants were involved in this study. Instead, magnetic flux and force data for three different helmet designs were collected using virtual simulation tools. A prototype helmet was then constructed and magnetic flux and force data were recorded and compared to virtual data. For both virtual and physical scenarios, magnitude and direction of the resulting forces were compared to determine which design created the controlled direction and strongest forces into the back of the eye. Of the three virtual designs, both designs containing a visor had greater force magnitude than magnet alone. Between both designs with visors, the visor with bends resulted in forces more directed at the back of the eye. The physical prototype helmet shared similar measurements to virtual simulation with minimal percent error (Average = 5.47%, Standard deviation = 0.03). Of the three designs, the visor with bends generated stronger forces directed at the back of the eye, which is most appropriate for creating a tamponade on the retina. We believe that this design has shown promising capability for manipulating intraocular MNPs for the purpose of creating a tamponade for RRD.
format	article
author	Evan Parker Chandler S. Mitchell Joshua P Smith Evan Carr Rasul Akbari Afshin Izadian Amir R Hajrasouliha
author_facet	Evan Parker Chandler S. Mitchell Joshua P Smith Evan Carr Rasul Akbari Afshin Izadian Amir R Hajrasouliha
author_sort	Evan Parker
title	Modeling of external self-excitation and force generation on magnetic nanoparticles inside vitreous cavity
title_short	Modeling of external self-excitation and force generation on magnetic nanoparticles inside vitreous cavity
title_full	Modeling of external self-excitation and force generation on magnetic nanoparticles inside vitreous cavity
title_fullStr	Modeling of external self-excitation and force generation on magnetic nanoparticles inside vitreous cavity
title_full_unstemmed	Modeling of external self-excitation and force generation on magnetic nanoparticles inside vitreous cavity
title_sort	modeling of external self-excitation and force generation on magnetic nanoparticles inside vitreous cavity
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/284398937bfc4cd79fe141e40d848bdc
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Modeling of external self-excitation and force generation on magnetic nanoparticles inside vitreous cavity

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