The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation

Excessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering, respectively, with IκBα activation and NLRP3-ASC...

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Autores principales:	Rojo A. Ratsimandresy, Lan H. Chu, Sonal Khare, Lucia de Almeida, Anu Gangopadhyay, Mohanalaxmi Indramohan, Alexander V. Misharin, David R. Greaves, Harris Perlman, Andrea Dorfleutner, Christian Stehlik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28458afcf61a49ae89fbff053e45bdf4
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spelling	oai:doaj.org-article:28458afcf61a49ae89fbff053e45bdf42021-12-02T14:41:09ZThe PYRIN domain-only protein POP2 inhibits inflammasome priming and activation10.1038/ncomms155562041-1723https://doaj.org/article/28458afcf61a49ae89fbff053e45bdf42017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15556https://doaj.org/toc/2041-1723Excessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering, respectively, with IκBα activation and NLRP3-ASC interaction.Rojo A. RatsimandresyLan H. ChuSonal KhareLucia de AlmeidaAnu GangopadhyayMohanalaxmi IndramohanAlexander V. MisharinDavid R. GreavesHarris PerlmanAndrea DorfleutnerChristian StehlikNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rojo A. Ratsimandresy Lan H. Chu Sonal Khare Lucia de Almeida Anu Gangopadhyay Mohanalaxmi Indramohan Alexander V. Misharin David R. Greaves Harris Perlman Andrea Dorfleutner Christian Stehlik The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
description	Excessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering, respectively, with IκBα activation and NLRP3-ASC interaction.
format	article
author	Rojo A. Ratsimandresy Lan H. Chu Sonal Khare Lucia de Almeida Anu Gangopadhyay Mohanalaxmi Indramohan Alexander V. Misharin David R. Greaves Harris Perlman Andrea Dorfleutner Christian Stehlik
author_facet	Rojo A. Ratsimandresy Lan H. Chu Sonal Khare Lucia de Almeida Anu Gangopadhyay Mohanalaxmi Indramohan Alexander V. Misharin David R. Greaves Harris Perlman Andrea Dorfleutner Christian Stehlik
author_sort	Rojo A. Ratsimandresy
title	The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
title_short	The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
title_full	The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
title_fullStr	The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
title_full_unstemmed	The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation
title_sort	pyrin domain-only protein pop2 inhibits inflammasome priming and activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/28458afcf61a49ae89fbff053e45bdf4
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The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation

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