Immune checkpoint modulation enhances HIV-1 antibody induction

Elucidation of broadly neutralizing antibodies (bnAb) is a goal in HIV vaccine development. Here, Bradley et al. show that administration of CTLA-4 blocking antibody with vaccine antigens increases HIV-1 envelope antibody responses in macaques and a bnAb precursor mouse model.

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Autores principales:	Todd Bradley, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, Cheng Cheng, Ali H. Ellebedy, Robert Parks, Maggie Barr, Laura L. Sutherland, Richard M. Scearce, Cindy M. Bowman, Hilary Bouton-Verville, Sampa Santra, Kevin Wiehe, Mark G. Lewis, Ane Ogbe, Persephone Borrow, David Montefiori, Mattia Bonsignori, M. Anthony Moody, Laurent Verkoczy, Kevin O. Saunders, Rafi Ahmed, John R. Mascola, Garnett Kelsoe, Frederick W. Alt, Barton F. Haynes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2846a0ffd9114ffb86364a75259018f1
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spelling	oai:doaj.org-article:2846a0ffd9114ffb86364a75259018f12021-12-02T15:39:29ZImmune checkpoint modulation enhances HIV-1 antibody induction10.1038/s41467-020-14670-w2041-1723https://doaj.org/article/2846a0ffd9114ffb86364a75259018f12020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14670-whttps://doaj.org/toc/2041-1723Elucidation of broadly neutralizing antibodies (bnAb) is a goal in HIV vaccine development. Here, Bradley et al. show that administration of CTLA-4 blocking antibody with vaccine antigens increases HIV-1 envelope antibody responses in macaques and a bnAb precursor mouse model.Todd BradleyMasayuki KuraokaChen-Hao YehMing TianHuan ChenDerek W. CainXuejun ChenCheng ChengAli H. EllebedyRobert ParksMaggie BarrLaura L. SutherlandRichard M. ScearceCindy M. BowmanHilary Bouton-VervilleSampa SantraKevin WieheMark G. LewisAne OgbePersephone BorrowDavid MontefioriMattia BonsignoriM. Anthony MoodyLaurent VerkoczyKevin O. SaundersRafi AhmedJohn R. MascolaGarnett KelsoeFrederick W. AltBarton F. HaynesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Todd Bradley Masayuki Kuraoka Chen-Hao Yeh Ming Tian Huan Chen Derek W. Cain Xuejun Chen Cheng Cheng Ali H. Ellebedy Robert Parks Maggie Barr Laura L. Sutherland Richard M. Scearce Cindy M. Bowman Hilary Bouton-Verville Sampa Santra Kevin Wiehe Mark G. Lewis Ane Ogbe Persephone Borrow David Montefiori Mattia Bonsignori M. Anthony Moody Laurent Verkoczy Kevin O. Saunders Rafi Ahmed John R. Mascola Garnett Kelsoe Frederick W. Alt Barton F. Haynes Immune checkpoint modulation enhances HIV-1 antibody induction
description	Elucidation of broadly neutralizing antibodies (bnAb) is a goal in HIV vaccine development. Here, Bradley et al. show that administration of CTLA-4 blocking antibody with vaccine antigens increases HIV-1 envelope antibody responses in macaques and a bnAb precursor mouse model.
format	article
author	Todd Bradley Masayuki Kuraoka Chen-Hao Yeh Ming Tian Huan Chen Derek W. Cain Xuejun Chen Cheng Cheng Ali H. Ellebedy Robert Parks Maggie Barr Laura L. Sutherland Richard M. Scearce Cindy M. Bowman Hilary Bouton-Verville Sampa Santra Kevin Wiehe Mark G. Lewis Ane Ogbe Persephone Borrow David Montefiori Mattia Bonsignori M. Anthony Moody Laurent Verkoczy Kevin O. Saunders Rafi Ahmed John R. Mascola Garnett Kelsoe Frederick W. Alt Barton F. Haynes
author_facet	Todd Bradley Masayuki Kuraoka Chen-Hao Yeh Ming Tian Huan Chen Derek W. Cain Xuejun Chen Cheng Cheng Ali H. Ellebedy Robert Parks Maggie Barr Laura L. Sutherland Richard M. Scearce Cindy M. Bowman Hilary Bouton-Verville Sampa Santra Kevin Wiehe Mark G. Lewis Ane Ogbe Persephone Borrow David Montefiori Mattia Bonsignori M. Anthony Moody Laurent Verkoczy Kevin O. Saunders Rafi Ahmed John R. Mascola Garnett Kelsoe Frederick W. Alt Barton F. Haynes
author_sort	Todd Bradley
title	Immune checkpoint modulation enhances HIV-1 antibody induction
title_short	Immune checkpoint modulation enhances HIV-1 antibody induction
title_full	Immune checkpoint modulation enhances HIV-1 antibody induction
title_fullStr	Immune checkpoint modulation enhances HIV-1 antibody induction
title_full_unstemmed	Immune checkpoint modulation enhances HIV-1 antibody induction
title_sort	immune checkpoint modulation enhances hiv-1 antibody induction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2846a0ffd9114ffb86364a75259018f1
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Immune checkpoint modulation enhances HIV-1 antibody induction

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