KIR/HLA ligands immunogenetics markers associated with outcome of hepatitis B virus infection in the Bulgarian population

Background. Hepatitis B virus (HBV) infection is one of the most common infections worldwide, having negative impact on world health due to the tendency for chronification with late complications such as liver cirrhosis and hepatocellular carcinoma. Natural killer (NK) cells as part of innate antivi...

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Autores principales:	Viktoria Varbanova, Georgi Popov, Veneta Grigorova, Diana Petrova, Elissaveta Naumova, Anastasiya Mihaylova
Formato:	article
Lenguaje:	EN
Publicado:	Palacký University Olomouc, Faculty of Medicine and Dentistry 2021
Materias:	killer immunoglobuline-like receptors kir hla ligands hepatitis b infection Medicine R
Acceso en línea:	https://doaj.org/article/284980eb3f2b4be6a371c6dd2533a6ea
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spelling	oai:doaj.org-article:284980eb3f2b4be6a371c6dd2533a6ea2021-11-29T08:47:12ZKIR/HLA ligands immunogenetics markers associated with outcome of hepatitis B virus infection in the Bulgarian population1213-81181804-752110.5507/bp.2020.043https://doaj.org/article/284980eb3f2b4be6a371c6dd2533a6ea2021-09-01T00:00:00Zhttps://biomed.papers.upol.cz/artkey/bio-202103-0006_kir-hla-ligands-immunogenetics-markers-associated-with-outcome-of-hepatitis-b-virus-infection-in-the-bulgarian.phphttps://doaj.org/toc/1213-8118https://doaj.org/toc/1804-7521Background. Hepatitis B virus (HBV) infection is one of the most common infections worldwide, having negative impact on world health due to the tendency for chronification with late complications such as liver cirrhosis and hepatocellular carcinoma. Natural killer (NK) cells as part of innate antiviral defense influence the clinical course of HBV infection: elimination of the virus or chronic disease. Aim. Therefore, we investigated the polymorphisms of the main gene systems, regulating NK-cell function: killer cell immunoglobulin-like receptors (KIRs) and their appropriate HLA class I ligands in 144 HBV infected patients (124 chronic carriers and 20 spontaneously recoved) and 126 ethnically matched healthy controls from the Bulgarian population in a case-control study. Methods. KIRs and HLA ligands were determined by PCR-SSP or PCR high-resolution typing methods. Results. KIR2DL5B allele variant was significantly less frequent in spontaneously recovered (SR) patients compared to healthy controls (10.0% vs. 45.5%, Pcorr=0.006). The presence of KIR3DL1*004 allele was higher in chronic HBV carriers (CH) than in controls (33.1% vs. 17.6%, Pcorr=0.036). Additionally, SR patients differed from healthy individuals by the lower frequency of HLA-Bw4Ile80 group ligands (30.0% vs 63.7%, P=0.015). Three KIR genotypes were found more frequent in healthy in comparison with HBV infected individuals: ID2 (13.5% vs 5.6%, P=0.025), KIR genotype containing 6 activating KIRs (18.0% vs 7.6%, P=0.017), and KIR genotype composed of 4 activating and 5 inhibitory KIRs (23.8% vs 5.6%, P=0.001). Conclusion. These data suggest that inherited KIR and HLA class I ligand polymorphisms may influence the clinical course of HBV infection.Viktoria VarbanovaGeorgi PopovVeneta GrigorovaDiana PetrovaElissaveta NaumovaAnastasiya MihaylovaPalacký University Olomouc, Faculty of Medicine and Dentistryarticlekiller immunoglobuline-like receptorskir hla ligandshepatitis b infectionMedicineRENBiomedical Papers, Vol 165, Iss 3, Pp 270-276 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	killer immunoglobuline-like receptors kir hla ligands hepatitis b infection Medicine R
spellingShingle	killer immunoglobuline-like receptors kir hla ligands hepatitis b infection Medicine R Viktoria Varbanova Georgi Popov Veneta Grigorova Diana Petrova Elissaveta Naumova Anastasiya Mihaylova KIR/HLA ligands immunogenetics markers associated with outcome of hepatitis B virus infection in the Bulgarian population
description	Background. Hepatitis B virus (HBV) infection is one of the most common infections worldwide, having negative impact on world health due to the tendency for chronification with late complications such as liver cirrhosis and hepatocellular carcinoma. Natural killer (NK) cells as part of innate antiviral defense influence the clinical course of HBV infection: elimination of the virus or chronic disease. Aim. Therefore, we investigated the polymorphisms of the main gene systems, regulating NK-cell function: killer cell immunoglobulin-like receptors (KIRs) and their appropriate HLA class I ligands in 144 HBV infected patients (124 chronic carriers and 20 spontaneously recoved) and 126 ethnically matched healthy controls from the Bulgarian population in a case-control study. Methods. KIRs and HLA ligands were determined by PCR-SSP or PCR high-resolution typing methods. Results. KIR2DL5B allele variant was significantly less frequent in spontaneously recovered (SR) patients compared to healthy controls (10.0% vs. 45.5%, Pcorr=0.006). The presence of KIR3DL1*004 allele was higher in chronic HBV carriers (CH) than in controls (33.1% vs. 17.6%, Pcorr=0.036). Additionally, SR patients differed from healthy individuals by the lower frequency of HLA-Bw4Ile80 group ligands (30.0% vs 63.7%, P=0.015). Three KIR genotypes were found more frequent in healthy in comparison with HBV infected individuals: ID2 (13.5% vs 5.6%, P=0.025), KIR genotype containing 6 activating KIRs (18.0% vs 7.6%, P=0.017), and KIR genotype composed of 4 activating and 5 inhibitory KIRs (23.8% vs 5.6%, P=0.001). Conclusion. These data suggest that inherited KIR and HLA class I ligand polymorphisms may influence the clinical course of HBV infection.
format	article
author	Viktoria Varbanova Georgi Popov Veneta Grigorova Diana Petrova Elissaveta Naumova Anastasiya Mihaylova
author_facet	Viktoria Varbanova Georgi Popov Veneta Grigorova Diana Petrova Elissaveta Naumova Anastasiya Mihaylova
author_sort	Viktoria Varbanova
title	KIR/HLA ligands immunogenetics markers associated with outcome of hepatitis B virus infection in the Bulgarian population
title_short	KIR/HLA ligands immunogenetics markers associated with outcome of hepatitis B virus infection in the Bulgarian population
title_full	KIR/HLA ligands immunogenetics markers associated with outcome of hepatitis B virus infection in the Bulgarian population
title_fullStr	KIR/HLA ligands immunogenetics markers associated with outcome of hepatitis B virus infection in the Bulgarian population
title_full_unstemmed	KIR/HLA ligands immunogenetics markers associated with outcome of hepatitis B virus infection in the Bulgarian population
title_sort	kir/hla ligands immunogenetics markers associated with outcome of hepatitis b virus infection in the bulgarian population
publisher	Palacký University Olomouc, Faculty of Medicine and Dentistry
publishDate	2021
url	https://doaj.org/article/284980eb3f2b4be6a371c6dd2533a6ea
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KIR/HLA ligands immunogenetics markers associated with outcome of hepatitis B virus infection in the Bulgarian population

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