Method comparison of beta‐hydroxybutyrate point‐of‐care testing to serum in healthy children

Abstract Ketone production is a physiological phenomenon that occurs to avoid irreversible neurological damage from hypoglycemia, thereby serving as a marker of metabolic stress. The primary ketone body, beta‐hydroxybutyrate (BHB), guides the diagnostic evaluation and management of many hypoglycemic...

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Autores principales:	Komalben Parmar, Maua Mosha, David A. Weinstein, Rebecca Riba‐Wolman
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	beta‐hydroxybutyrate ketone comparison ketotic hypoglycemia point of care precision Xtra ketone meter Diseases of the endocrine glands. Clinical endocrinology RC648-665 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/284e2d5fcf3746a48d384b3fe11af57a
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spelling	oai:doaj.org-article:284e2d5fcf3746a48d384b3fe11af57a2021-11-08T13:27:19ZMethod comparison of beta‐hydroxybutyrate point‐of‐care testing to serum in healthy children2192-831210.1002/jmd2.12245https://doaj.org/article/284e2d5fcf3746a48d384b3fe11af57a2021-11-01T00:00:00Zhttps://doi.org/10.1002/jmd2.12245https://doaj.org/toc/2192-8312Abstract Ketone production is a physiological phenomenon that occurs to avoid irreversible neurological damage from hypoglycemia, thereby serving as a marker of metabolic stress. The primary ketone body, beta‐hydroxybutyrate (BHB), guides the diagnostic evaluation and management of many hypoglycemic disorders. Serum and point‐of‐care (POC) BHB values were not been compared in children without diabetes or metabolic disorders. We aim at comparing the serum and point‐of‐care BHB values in healthy children after an overnight fast. Eligible participants were ≤18 years of age prospectively recruited from elective procedures through our surgery centers. Exclusion criteria included a history of diabetes, hypopituitarism, adrenal, metabolic or inflammatory disorders, dietary restrictions, trauma, or use of medications that might affect blood glucose. The main outcome measure was comparing serum and POC BHB levels after a period of fasting. Data from 94 participants (mean age 8.29 ± 5.68 years, 54.3% male, 45.7% female, BMI mean 19.28 ± 5.25 kg/m2) were analyzed. There was a strong correlation between serum BHB (mean 0.25 ± 0.23 mmol/L) and POC BHB (mean 0.18 ± 0.20 mmol/L) (rs = 0.803, p < 0.0001). The majority (96.81%) of values for serum BHB compared with POC BHB fell within 0.1 ± 0.1 mmol/L. The average of difference between serum and POC BHB (the bias) was 0.064 mmol/L (95% CI 0.047–0.081), and percentage error was 3.19%. Point‐of‐care BHB is accurate and comparable to serum BHB levels in our cohort of children after an overnight fast. Synopsis Point‐of‐care BHB agrees with serum values in healthy children.Komalben ParmarMaua MoshaDavid A. WeinsteinRebecca Riba‐WolmanWileyarticlebeta‐hydroxybutyrateketone comparisonketotic hypoglycemiapoint of careprecision Xtra ketone meterDiseases of the endocrine glands. Clinical endocrinologyRC648-665GeneticsQH426-470ENJIMD Reports, Vol 62, Iss 1, Pp 85-90 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	beta‐hydroxybutyrate ketone comparison ketotic hypoglycemia point of care precision Xtra ketone meter Diseases of the endocrine glands. Clinical endocrinology RC648-665 Genetics QH426-470
spellingShingle	beta‐hydroxybutyrate ketone comparison ketotic hypoglycemia point of care precision Xtra ketone meter Diseases of the endocrine glands. Clinical endocrinology RC648-665 Genetics QH426-470 Komalben Parmar Maua Mosha David A. Weinstein Rebecca Riba‐Wolman Method comparison of beta‐hydroxybutyrate point‐of‐care testing to serum in healthy children
description	Abstract Ketone production is a physiological phenomenon that occurs to avoid irreversible neurological damage from hypoglycemia, thereby serving as a marker of metabolic stress. The primary ketone body, beta‐hydroxybutyrate (BHB), guides the diagnostic evaluation and management of many hypoglycemic disorders. Serum and point‐of‐care (POC) BHB values were not been compared in children without diabetes or metabolic disorders. We aim at comparing the serum and point‐of‐care BHB values in healthy children after an overnight fast. Eligible participants were ≤18 years of age prospectively recruited from elective procedures through our surgery centers. Exclusion criteria included a history of diabetes, hypopituitarism, adrenal, metabolic or inflammatory disorders, dietary restrictions, trauma, or use of medications that might affect blood glucose. The main outcome measure was comparing serum and POC BHB levels after a period of fasting. Data from 94 participants (mean age 8.29 ± 5.68 years, 54.3% male, 45.7% female, BMI mean 19.28 ± 5.25 kg/m2) were analyzed. There was a strong correlation between serum BHB (mean 0.25 ± 0.23 mmol/L) and POC BHB (mean 0.18 ± 0.20 mmol/L) (rs = 0.803, p < 0.0001). The majority (96.81%) of values for serum BHB compared with POC BHB fell within 0.1 ± 0.1 mmol/L. The average of difference between serum and POC BHB (the bias) was 0.064 mmol/L (95% CI 0.047–0.081), and percentage error was 3.19%. Point‐of‐care BHB is accurate and comparable to serum BHB levels in our cohort of children after an overnight fast. Synopsis Point‐of‐care BHB agrees with serum values in healthy children.
format	article
author	Komalben Parmar Maua Mosha David A. Weinstein Rebecca Riba‐Wolman
author_facet	Komalben Parmar Maua Mosha David A. Weinstein Rebecca Riba‐Wolman
author_sort	Komalben Parmar
title	Method comparison of beta‐hydroxybutyrate point‐of‐care testing to serum in healthy children
title_short	Method comparison of beta‐hydroxybutyrate point‐of‐care testing to serum in healthy children
title_full	Method comparison of beta‐hydroxybutyrate point‐of‐care testing to serum in healthy children
title_fullStr	Method comparison of beta‐hydroxybutyrate point‐of‐care testing to serum in healthy children
title_full_unstemmed	Method comparison of beta‐hydroxybutyrate point‐of‐care testing to serum in healthy children
title_sort	method comparison of beta‐hydroxybutyrate point‐of‐care testing to serum in healthy children
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/284e2d5fcf3746a48d384b3fe11af57a
work_keys_str_mv	AT komalbenparmar methodcomparisonofbetahydroxybutyratepointofcaretestingtoseruminhealthychildren AT mauamosha methodcomparisonofbetahydroxybutyratepointofcaretestingtoseruminhealthychildren AT davidaweinstein methodcomparisonofbetahydroxybutyratepointofcaretestingtoseruminhealthychildren AT rebeccaribawolman methodcomparisonofbetahydroxybutyratepointofcaretestingtoseruminhealthychildren
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Method comparison of beta‐hydroxybutyrate point‐of‐care testing to serum in healthy children

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