Tumor Budding Score Is a Strong and Independent Prognostic Factor in Patients With Pancreatic Ductal Adenocarcinoma: An Evaluation of Whole Slide Pathology Images of Large Sections
ObjectiveWe aimed to develop the tumor budding (TB) score and to explore the association between the TB score and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC).MethodsIn this retrospective study, 130 consecutive patients with PDAC underwent surgical resection between...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2850a9064bcd4a64ba5066ccb5e9f4ed |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:2850a9064bcd4a64ba5066ccb5e9f4ed |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:2850a9064bcd4a64ba5066ccb5e9f4ed2021-12-01T14:54:49ZTumor Budding Score Is a Strong and Independent Prognostic Factor in Patients With Pancreatic Ductal Adenocarcinoma: An Evaluation of Whole Slide Pathology Images of Large Sections2234-943X10.3389/fonc.2021.740212https://doaj.org/article/2850a9064bcd4a64ba5066ccb5e9f4ed2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.740212/fullhttps://doaj.org/toc/2234-943XObjectiveWe aimed to develop the tumor budding (TB) score and to explore the association between the TB score and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC).MethodsIn this retrospective study, 130 consecutive patients with PDAC underwent surgical resection between July 2016 and March 2019. The location and counts of TB were assessed based on the digitalized whole slide hematoxylin and eosin images. The TB score was achieved using the Cox regression equation. The cutoff point for the TB score was determined by X-tile. Univariate and multivariate Cox regression models were used to analyze the association between the TB score and OS.ResultsThe TB score was 0.49 (range = 0–1.08), and the best cutoff for the TB score was 0.62. The duration of survival in individuals with a low TB score [median = 21.8 months, 95% confidence interval (CI) = 15.43–25.50] was significantly longer than that in those with a high TB score (median = 11.33 months, 95% CI = 9.8–14.22). Univariate analysis revealed that the TB score was significantly associated with OS [hazard ratio (HR) = 2.71, 95% CI = 1.48–4.96, p = 0.001]. Multivariate analysis revealed a strong and independent association between the TB score and OS (HR = 2.35, 95% CI = 1.27–4.33, p = 0.03). The high TB score group had a 2.14 times higher mortality than the low TB score group.ConclusionThe TB score is strongly and independently associated with the risk of OS in PDAC.Hui JiangYelin YangYuping QianChengwei ShaoJianping LuYun BianJianming ZhengFrontiers Media S.A.articlepancreatic neoplasmcarcinomatumor buddingprognosissurvivalneoplasm stagingNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
pancreatic neoplasm carcinoma tumor budding prognosis survival neoplasm staging Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
pancreatic neoplasm carcinoma tumor budding prognosis survival neoplasm staging Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hui Jiang Yelin Yang Yuping Qian Chengwei Shao Jianping Lu Yun Bian Jianming Zheng Tumor Budding Score Is a Strong and Independent Prognostic Factor in Patients With Pancreatic Ductal Adenocarcinoma: An Evaluation of Whole Slide Pathology Images of Large Sections |
| description |
ObjectiveWe aimed to develop the tumor budding (TB) score and to explore the association between the TB score and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC).MethodsIn this retrospective study, 130 consecutive patients with PDAC underwent surgical resection between July 2016 and March 2019. The location and counts of TB were assessed based on the digitalized whole slide hematoxylin and eosin images. The TB score was achieved using the Cox regression equation. The cutoff point for the TB score was determined by X-tile. Univariate and multivariate Cox regression models were used to analyze the association between the TB score and OS.ResultsThe TB score was 0.49 (range = 0–1.08), and the best cutoff for the TB score was 0.62. The duration of survival in individuals with a low TB score [median = 21.8 months, 95% confidence interval (CI) = 15.43–25.50] was significantly longer than that in those with a high TB score (median = 11.33 months, 95% CI = 9.8–14.22). Univariate analysis revealed that the TB score was significantly associated with OS [hazard ratio (HR) = 2.71, 95% CI = 1.48–4.96, p = 0.001]. Multivariate analysis revealed a strong and independent association between the TB score and OS (HR = 2.35, 95% CI = 1.27–4.33, p = 0.03). The high TB score group had a 2.14 times higher mortality than the low TB score group.ConclusionThe TB score is strongly and independently associated with the risk of OS in PDAC. |
| format |
article |
| author |
Hui Jiang Yelin Yang Yuping Qian Chengwei Shao Jianping Lu Yun Bian Jianming Zheng |
| author_facet |
Hui Jiang Yelin Yang Yuping Qian Chengwei Shao Jianping Lu Yun Bian Jianming Zheng |
| author_sort |
Hui Jiang |
| title |
Tumor Budding Score Is a Strong and Independent Prognostic Factor in Patients With Pancreatic Ductal Adenocarcinoma: An Evaluation of Whole Slide Pathology Images of Large Sections |
| title_short |
Tumor Budding Score Is a Strong and Independent Prognostic Factor in Patients With Pancreatic Ductal Adenocarcinoma: An Evaluation of Whole Slide Pathology Images of Large Sections |
| title_full |
Tumor Budding Score Is a Strong and Independent Prognostic Factor in Patients With Pancreatic Ductal Adenocarcinoma: An Evaluation of Whole Slide Pathology Images of Large Sections |
| title_fullStr |
Tumor Budding Score Is a Strong and Independent Prognostic Factor in Patients With Pancreatic Ductal Adenocarcinoma: An Evaluation of Whole Slide Pathology Images of Large Sections |
| title_full_unstemmed |
Tumor Budding Score Is a Strong and Independent Prognostic Factor in Patients With Pancreatic Ductal Adenocarcinoma: An Evaluation of Whole Slide Pathology Images of Large Sections |
| title_sort |
tumor budding score is a strong and independent prognostic factor in patients with pancreatic ductal adenocarcinoma: an evaluation of whole slide pathology images of large sections |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/2850a9064bcd4a64ba5066ccb5e9f4ed |
| work_keys_str_mv |
AT huijiang tumorbuddingscoreisastrongandindependentprognosticfactorinpatientswithpancreaticductaladenocarcinomaanevaluationofwholeslidepathologyimagesoflargesections AT yelinyang tumorbuddingscoreisastrongandindependentprognosticfactorinpatientswithpancreaticductaladenocarcinomaanevaluationofwholeslidepathologyimagesoflargesections AT yupingqian tumorbuddingscoreisastrongandindependentprognosticfactorinpatientswithpancreaticductaladenocarcinomaanevaluationofwholeslidepathologyimagesoflargesections AT chengweishao tumorbuddingscoreisastrongandindependentprognosticfactorinpatientswithpancreaticductaladenocarcinomaanevaluationofwholeslidepathologyimagesoflargesections AT jianpinglu tumorbuddingscoreisastrongandindependentprognosticfactorinpatientswithpancreaticductaladenocarcinomaanevaluationofwholeslidepathologyimagesoflargesections AT yunbian tumorbuddingscoreisastrongandindependentprognosticfactorinpatientswithpancreaticductaladenocarcinomaanevaluationofwholeslidepathologyimagesoflargesections AT jianmingzheng tumorbuddingscoreisastrongandindependentprognosticfactorinpatientswithpancreaticductaladenocarcinomaanevaluationofwholeslidepathologyimagesoflargesections |
| _version_ |
1718404860411379712 |