Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

Elevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The consequent impairment of insulin signaling can be rescu...

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Autores principales:	Jia Cao, Jinghua Peng, Hongying An, Qiyi He, Tatiana Boronina, Shaodong Guo, Morris F. White, Philip A. Cole, Ling He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/285554089e9548a3b4c4378a2f0a5555
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spelling	oai:doaj.org-article:285554089e9548a3b4c4378a2f0a55552021-12-02T13:57:44ZEndotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity10.1038/s41467-017-00163-w2041-1723https://doaj.org/article/285554089e9548a3b4c4378a2f0a55552017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00163-whttps://doaj.org/toc/2041-1723Elevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The consequent impairment of insulin signaling can be rescued by pharmacological inhibition of P300.Jia CaoJinghua PengHongying AnQiyi HeTatiana BoroninaShaodong GuoMorris F. WhitePhilip A. ColeLing HeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jia Cao Jinghua Peng Hongying An Qiyi He Tatiana Boronina Shaodong Guo Morris F. White Philip A. Cole Ling He Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
description	Elevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The consequent impairment of insulin signaling can be rescued by pharmacological inhibition of P300.
format	article
author	Jia Cao Jinghua Peng Hongying An Qiyi He Tatiana Boronina Shaodong Guo Morris F. White Philip A. Cole Ling He
author_facet	Jia Cao Jinghua Peng Hongying An Qiyi He Tatiana Boronina Shaodong Guo Morris F. White Philip A. Cole Ling He
author_sort	Jia Cao
title	Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
title_short	Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
title_full	Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
title_fullStr	Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
title_full_unstemmed	Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
title_sort	endotoxemia-mediated activation of acetyltransferase p300 impairs insulin signaling in obesity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/285554089e9548a3b4c4378a2f0a5555
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Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

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