Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity
Elevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The consequent impairment of insulin signaling can be rescu...
Guardado en:
Autores principales: | Jia Cao, Jinghua Peng, Hongying An, Qiyi He, Tatiana Boronina, Shaodong Guo, Morris F. White, Philip A. Cole, Ling He |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/285554089e9548a3b4c4378a2f0a5555 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Short-chain fatty acids activate acetyltransferase p300
por: Sydney P Thomas, et al.
Publicado: (2021) -
Polymerized albumin restores impaired hemodynamics in endotoxemia and polymicrobial sepsis
por: Donald A. Belcher, et al.
Publicado: (2021) -
Insulin hypersensitivity induced by hepatic PTEN gene ablation protects from murine endotoxemia.
por: Philipp M Guenzl, et al.
Publicado: (2013) -
Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cellular Aging-Related Cardiovascular Disease
por: Asish K. Ghosh
Publicado: (2021) -
Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion
por: Fangfang Zhang, et al.
Publicado: (2020)