The right time for senescence
Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cel...
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eLife Sciences Publications Ltd
2021
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oai:doaj.org-article:28587e67f11245f4ba9f5d67b7f05e292021-11-10T13:01:44ZThe right time for senescence10.7554/eLife.724492050-084Xe72449https://doaj.org/article/28587e67f11245f4ba9f5d67b7f05e292021-11-01T00:00:00Zhttps://elifesciences.org/articles/72449https://doaj.org/toc/2050-084XCellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biological processes like tissue remodelling, injury and cancer. The development of new tools to study senescence in vivo paved the way to uncover its functional roles in various frameworks, which are sometimes hard to reconcile. Here, we review the functional impact of senescent cells on different organismal contexts. We provide updated insights on the role of senescent cells in tissue repair and regeneration, in which they essentially modulate the levels of fibrosis and inflammation, discussing how “time” seems to be the key maestro of their effects. Finally, we overview the current clinical research landscape to target senescent cells and contemplate its repercussions on this fast-evolving field.Diogo Paramos-de-CarvalhoAntonio JacintoLeonor SaúdeeLife Sciences Publications Ltdarticlesenescencetimetissue remodellingpathophysiologysenotherapiesMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
senescence time tissue remodelling pathophysiology senotherapies Medicine R Science Q Biology (General) QH301-705.5 |
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senescence time tissue remodelling pathophysiology senotherapies Medicine R Science Q Biology (General) QH301-705.5 Diogo Paramos-de-Carvalho Antonio Jacinto Leonor Saúde The right time for senescence |
| description |
Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biological processes like tissue remodelling, injury and cancer. The development of new tools to study senescence in vivo paved the way to uncover its functional roles in various frameworks, which are sometimes hard to reconcile. Here, we review the functional impact of senescent cells on different organismal contexts. We provide updated insights on the role of senescent cells in tissue repair and regeneration, in which they essentially modulate the levels of fibrosis and inflammation, discussing how “time” seems to be the key maestro of their effects. Finally, we overview the current clinical research landscape to target senescent cells and contemplate its repercussions on this fast-evolving field. |
| format |
article |
| author |
Diogo Paramos-de-Carvalho Antonio Jacinto Leonor Saúde |
| author_facet |
Diogo Paramos-de-Carvalho Antonio Jacinto Leonor Saúde |
| author_sort |
Diogo Paramos-de-Carvalho |
| title |
The right time for senescence |
| title_short |
The right time for senescence |
| title_full |
The right time for senescence |
| title_fullStr |
The right time for senescence |
| title_full_unstemmed |
The right time for senescence |
| title_sort |
right time for senescence |
| publisher |
eLife Sciences Publications Ltd |
| publishDate |
2021 |
| url |
https://doaj.org/article/28587e67f11245f4ba9f5d67b7f05e29 |
| work_keys_str_mv |
AT diogoparamosdecarvalho therighttimeforsenescence AT antoniojacinto therighttimeforsenescence AT leonorsaude therighttimeforsenescence AT diogoparamosdecarvalho righttimeforsenescence AT antoniojacinto righttimeforsenescence AT leonorsaude righttimeforsenescence |
| _version_ |
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