A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with activation of hemolysin-mediated host cell pyroptosis.

Uropathogenic Escherichia coli (UPEC) deploy an array of virulence factors to successfully establish urinary tract infections. Hemolysin is a pore-forming toxin, and its expression correlates with the severity of UPEC infection. Two-component signaling systems (TCSs) are a major mechanism by which b...

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Autores principales: Hongwei Gu, Xuwang Cai, Xinyang Zhang, Jie Luo, Xiaoyang Zhang, Xiao Hu, Wentong Cai, Ganwu Li
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/285a749719fb4ae688f73a7c5d0b8d88
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