Serial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan

Abstract Lung ultrasound (LUS) is a promising point-of-care imaging technology for diagnosing and managing pneumonia. We sought to explore serial LUS examinations in children with chest-indrawing pneumonia in resource-constrained settings and compare their clinical and LUS imaging courses longitudin...

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Autores principales:	Amy Sarah Ginsburg, Imran Nisar, Lola Madrid, Jennifer L. Lenahan, Benazir Balouch, Pio Vitorino, Jun Hwang, Alessandro Lamorte, Neel Kanth, Rubao Bila, Marta Valente, Rosauro Varo, Susanne May, Quique Bassat, Fyezah Jehan, Giovanni Volpicelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/285b06e0819948c2a33dc1db2c3975e2
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spelling	oai:doaj.org-article:285b06e0819948c2a33dc1db2c3975e22021-12-02T13:17:42ZSerial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan10.1038/s41598-021-85485-y2045-2322https://doaj.org/article/285b06e0819948c2a33dc1db2c3975e22021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85485-yhttps://doaj.org/toc/2045-2322Abstract Lung ultrasound (LUS) is a promising point-of-care imaging technology for diagnosing and managing pneumonia. We sought to explore serial LUS examinations in children with chest-indrawing pneumonia in resource-constrained settings and compare their clinical and LUS imaging courses longitudinally. We conducted a prospective, observational study among children aged 2 through 23 months with World Health Organization Integrated Management of Childhood Illness chest-indrawing pneumonia and among children without fast breathing, chest indrawing or fever (no pneumonia cohort) at 2 district hospitals in Mozambique and Pakistan. We assessed serial LUS at enrollment, 2, 6, and 14 days, and performed a secondary analysis of enrolled children’s longitudinal clinical and imaging courses. By Day 14, the majority of children with chest-indrawing pneumonia and consolidation on enrollment LUS showed improvement on follow-up LUS (100% in Mozambique, 85.4% in Pakistan) and were clinically cured (100% in Mozambique, 78.0% in Pakistan). In our cohort of children with chest-indrawing pneumonia, LUS imaging often reflected the clinical course; however, it is unclear how serial LUS would inform the routine management of non-severe chest-indrawing pneumonia.Amy Sarah GinsburgImran NisarLola MadridJennifer L. LenahanBenazir BalouchPio VitorinoJun HwangAlessandro LamorteNeel KanthRubao BilaMarta ValenteRosauro VaroSusanne MayQuique BassatFyezah JehanGiovanni VolpicelliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amy Sarah Ginsburg Imran Nisar Lola Madrid Jennifer L. Lenahan Benazir Balouch Pio Vitorino Jun Hwang Alessandro Lamorte Neel Kanth Rubao Bila Marta Valente Rosauro Varo Susanne May Quique Bassat Fyezah Jehan Giovanni Volpicelli Serial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan
description	Abstract Lung ultrasound (LUS) is a promising point-of-care imaging technology for diagnosing and managing pneumonia. We sought to explore serial LUS examinations in children with chest-indrawing pneumonia in resource-constrained settings and compare their clinical and LUS imaging courses longitudinally. We conducted a prospective, observational study among children aged 2 through 23 months with World Health Organization Integrated Management of Childhood Illness chest-indrawing pneumonia and among children without fast breathing, chest indrawing or fever (no pneumonia cohort) at 2 district hospitals in Mozambique and Pakistan. We assessed serial LUS at enrollment, 2, 6, and 14 days, and performed a secondary analysis of enrolled children’s longitudinal clinical and imaging courses. By Day 14, the majority of children with chest-indrawing pneumonia and consolidation on enrollment LUS showed improvement on follow-up LUS (100% in Mozambique, 85.4% in Pakistan) and were clinically cured (100% in Mozambique, 78.0% in Pakistan). In our cohort of children with chest-indrawing pneumonia, LUS imaging often reflected the clinical course; however, it is unclear how serial LUS would inform the routine management of non-severe chest-indrawing pneumonia.
format	article
author	Amy Sarah Ginsburg Imran Nisar Lola Madrid Jennifer L. Lenahan Benazir Balouch Pio Vitorino Jun Hwang Alessandro Lamorte Neel Kanth Rubao Bila Marta Valente Rosauro Varo Susanne May Quique Bassat Fyezah Jehan Giovanni Volpicelli
author_facet	Amy Sarah Ginsburg Imran Nisar Lola Madrid Jennifer L. Lenahan Benazir Balouch Pio Vitorino Jun Hwang Alessandro Lamorte Neel Kanth Rubao Bila Marta Valente Rosauro Varo Susanne May Quique Bassat Fyezah Jehan Giovanni Volpicelli
author_sort	Amy Sarah Ginsburg
title	Serial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan
title_short	Serial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan
title_full	Serial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan
title_fullStr	Serial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan
title_full_unstemmed	Serial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan
title_sort	serial lung ultrasounds in pediatric pneumonia in mozambique and pakistan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/285b06e0819948c2a33dc1db2c3975e2
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Serial lung ultrasounds in pediatric pneumonia in Mozambique and Pakistan

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