Airway inflammation in patients with bronchiectasis

Bronchiectasis is a chronic lung disease characterized by an abnormal dilation of the bronchial lumen caused by weakening or destruction of the muscle or elastic components of the bronchial wall, decreased mucous clearance and frequent infections of the respiratory tract. The golden standard for bro...

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Autores principales:	Đurđević Nataša, Milenković Branislava, Janković Jelena, Mitić Javorka, Belić Slobodan, Jordanova Elena, Baralić Marko
Formato:	article
Lenguaje:	EN SR
Publicado:	City Medical emergency department, Belgrade 2021
Materias:	bronchiectasis infection inflammation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/285d8990938e4820bebf2080b683fdec
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spelling	oai:doaj.org-article:285d8990938e4820bebf2080b683fdec2021-12-05T21:18:47ZAirway inflammation in patients with bronchiectasis2334-647710.5937/halo27-31410https://doaj.org/article/285d8990938e4820bebf2080b683fdec2021-01-01T00:00:00Zhttps://scindeks-clanci.ceon.rs/data/pdf/2334-6477/2021/2334-64772102068Q.pdfhttps://doaj.org/toc/2334-6477Bronchiectasis is a chronic lung disease characterized by an abnormal dilation of the bronchial lumen caused by weakening or destruction of the muscle or elastic components of the bronchial wall, decreased mucous clearance and frequent infections of the respiratory tract. The golden standard for bronchiectasis diagnosis is high-resolution computed tomography (HRCT) of the chest. Inflammation holds a central role in the development of structural lung changes, as well as airway and lung parenchyma damage. Infection and colonization of the respiratory tract contribute to increased inflammation and further damage to the lung. Upon entry into the respiratory tract, the pathogens activate epithelial cells, macrophages and dendritic cells. Activated inflammatory cells secrete chemical mediators which activate the immune response and thus allow the phagocytosis of pathogens. Early diagnosis, appropriate treatment and interruption of the vicious circle between infection and inflammation in patients suffering from bronchiectasis, prevent the development of structural changes to the airways.Đurđević NatašaMilenković BranislavaJanković JelenaMitić JavorkaBelić SlobodanJordanova ElenaBaralić MarkoCity Medical emergency department, BelgradearticlebronchiectasisinfectioninflammationMedicine (General)R5-920ENSRHalo 194, Vol 27, Iss 2, Pp 68-72 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	bronchiectasis infection inflammation Medicine (General) R5-920
spellingShingle	bronchiectasis infection inflammation Medicine (General) R5-920 Đurđević Nataša Milenković Branislava Janković Jelena Mitić Javorka Belić Slobodan Jordanova Elena Baralić Marko Airway inflammation in patients with bronchiectasis
description	Bronchiectasis is a chronic lung disease characterized by an abnormal dilation of the bronchial lumen caused by weakening or destruction of the muscle or elastic components of the bronchial wall, decreased mucous clearance and frequent infections of the respiratory tract. The golden standard for bronchiectasis diagnosis is high-resolution computed tomography (HRCT) of the chest. Inflammation holds a central role in the development of structural lung changes, as well as airway and lung parenchyma damage. Infection and colonization of the respiratory tract contribute to increased inflammation and further damage to the lung. Upon entry into the respiratory tract, the pathogens activate epithelial cells, macrophages and dendritic cells. Activated inflammatory cells secrete chemical mediators which activate the immune response and thus allow the phagocytosis of pathogens. Early diagnosis, appropriate treatment and interruption of the vicious circle between infection and inflammation in patients suffering from bronchiectasis, prevent the development of structural changes to the airways.
format	article
author	Đurđević Nataša Milenković Branislava Janković Jelena Mitić Javorka Belić Slobodan Jordanova Elena Baralić Marko
author_facet	Đurđević Nataša Milenković Branislava Janković Jelena Mitić Javorka Belić Slobodan Jordanova Elena Baralić Marko
author_sort	Đurđević Nataša
title	Airway inflammation in patients with bronchiectasis
title_short	Airway inflammation in patients with bronchiectasis
title_full	Airway inflammation in patients with bronchiectasis
title_fullStr	Airway inflammation in patients with bronchiectasis
title_full_unstemmed	Airway inflammation in patients with bronchiectasis
title_sort	airway inflammation in patients with bronchiectasis
publisher	City Medical emergency department, Belgrade
publishDate	2021
url	https://doaj.org/article/285d8990938e4820bebf2080b683fdec
work_keys_str_mv	AT đurđevicnatasa airwayinflammationinpatientswithbronchiectasis AT milenkovicbranislava airwayinflammationinpatientswithbronchiectasis AT jankovicjelena airwayinflammationinpatientswithbronchiectasis AT miticjavorka airwayinflammationinpatientswithbronchiectasis AT belicslobodan airwayinflammationinpatientswithbronchiectasis AT jordanovaelena airwayinflammationinpatientswithbronchiectasis AT baralicmarko airwayinflammationinpatientswithbronchiectasis
_version_	1718370991191621632

Airway inflammation in patients with bronchiectasis

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