Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons

Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons

Oxytocin (OXT) has been implicated in adult neurogenesis. Here the authors show that CA3 pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons; activation of OXT signaling in CA3 pyramidal cells promotes the survival and maturation of n...

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Autores principales: Yu-Ting Lin, Chien-Chung Chen, Chiung-Chun Huang, Katsuhiko Nishimori, Kuei-Sen Hsu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/28605a40fc4e460f9dc10d9d07344dc1
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spelling oai:doaj.org-article:28605a40fc4e460f9dc10d9d07344dc12021-12-02T17:01:18ZOxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons10.1038/s41467-017-00675-52041-1723https://doaj.org/article/28605a40fc4e460f9dc10d9d07344dc12017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00675-5https://doaj.org/toc/2041-1723Oxytocin (OXT) has been implicated in adult neurogenesis. Here the authors show that CA3 pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons; activation of OXT signaling in CA3 pyramidal cells promotes the survival and maturation of newborn neurons in the dentate gyrus in a non-cell autonomous manner.Yu-Ting LinChien-Chung ChenChiung-Chun HuangKatsuhiko NishimoriKuei-Sen HsuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yu-Ting Lin
Chien-Chung Chen
Chiung-Chun Huang
Katsuhiko Nishimori
Kuei-Sen Hsu
Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons
description Oxytocin (OXT) has been implicated in adult neurogenesis. Here the authors show that CA3 pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons; activation of OXT signaling in CA3 pyramidal cells promotes the survival and maturation of newborn neurons in the dentate gyrus in a non-cell autonomous manner.
format article
author Yu-Ting Lin
Chien-Chung Chen
Chiung-Chun Huang
Katsuhiko Nishimori
Kuei-Sen Hsu
author_facet Yu-Ting Lin
Chien-Chung Chen
Chiung-Chun Huang
Katsuhiko Nishimori
Kuei-Sen Hsu
author_sort Yu-Ting Lin
title Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons
title_short Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons
title_full Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons
title_fullStr Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons
title_full_unstemmed Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons
title_sort oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in ca3 pyramidal neurons
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/28605a40fc4e460f9dc10d9d07344dc1
work_keys_str_mv AT yutinglin oxytocinstimulateshippocampalneurogenesisviaoxytocinreceptorexpressedinca3pyramidalneurons
AT chienchungchen oxytocinstimulateshippocampalneurogenesisviaoxytocinreceptorexpressedinca3pyramidalneurons
AT chiungchunhuang oxytocinstimulateshippocampalneurogenesisviaoxytocinreceptorexpressedinca3pyramidalneurons
AT katsuhikonishimori oxytocinstimulateshippocampalneurogenesisviaoxytocinreceptorexpressedinca3pyramidalneurons
AT kueisenhsu oxytocinstimulateshippocampalneurogenesisviaoxytocinreceptorexpressedinca3pyramidalneurons
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