Prevention of ischemic stroke in atrial fibrillation from the point of view of a neurologist. Standards and real clinical practice

The article outlines aspects of the current state of the problem of the priority choice of an oral anticoagulant for indefinite prevention of stroke and systemic thromboembolism in patients with atrial fibrillation. The advantages of direct oral angicoagulants over warfarin are presented, as well as...

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Autores principales:	Marina Yu. Maksimova, Andrei V. Fonyakin, Liudmila A. Geraskina
Formato:	article
Lenguaje:	RU
Publicado:	"Consilium Medicum" Publishing house 2021
Materias:	stroke prevention atrial fibrillation oral anticoagulants therapy personalization Medicine R
Acceso en línea:	https://doaj.org/article/286137aa30ec4ae78394a2f3330bed9d
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spelling	oai:doaj.org-article:286137aa30ec4ae78394a2f3330bed9d2021-12-01T12:22:37ZPrevention of ischemic stroke in atrial fibrillation from the point of view of a neurologist. Standards and real clinical practice0040-36602309-534210.26442/00403660.2021.10.201105https://doaj.org/article/286137aa30ec4ae78394a2f3330bed9d2021-10-01T00:00:00Zhttps://ter-arkhiv.ru/0040-3660/article/viewFile/87148/65327https://doaj.org/toc/0040-3660https://doaj.org/toc/2309-5342The article outlines aspects of the current state of the problem of the priority choice of an oral anticoagulant for indefinite prevention of stroke and systemic thromboembolism in patients with atrial fibrillation. The advantages of direct oral angicoagulants over warfarin are presented, as well as a comparative analysis of the individual characteristics of the main direct oral angicoagulants from the point of view of personification of preventive therapy in accordance with modern treatment standards. The efficacy and safety of oral anticoagulant therapy has been reviewed in terms of the net clinical benefit. Particular attention is paid to the age-related aspects of choosing an anticoagulant for indefinite prophylaxis; an assessment of anticoagulants is presented in accordance with the FORTA concept, which regulates the use of drugs in elderly patients. In conclusion, recommendations are formulated for the choice of an anticoagulant in patients with atrial fibrillation in the most common clinical situations. As a general rule, the choice of a particular drug should be individualized based on risk factors, tolerability, net clinical benefit, patient preference, potential adverse interactions, and other clinical characteristics.Marina Yu. MaksimovaAndrei V. FonyakinLiudmila A. Geraskina"Consilium Medicum" Publishing housearticlestroke preventionatrial fibrillationoral anticoagulantstherapy personalizationMedicineRRUТерапевтический архив, Vol 93, Iss 10, Pp 1240-1245 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	stroke prevention atrial fibrillation oral anticoagulants therapy personalization Medicine R
spellingShingle	stroke prevention atrial fibrillation oral anticoagulants therapy personalization Medicine R Marina Yu. Maksimova Andrei V. Fonyakin Liudmila A. Geraskina Prevention of ischemic stroke in atrial fibrillation from the point of view of a neurologist. Standards and real clinical practice
description	The article outlines aspects of the current state of the problem of the priority choice of an oral anticoagulant for indefinite prevention of stroke and systemic thromboembolism in patients with atrial fibrillation. The advantages of direct oral angicoagulants over warfarin are presented, as well as a comparative analysis of the individual characteristics of the main direct oral angicoagulants from the point of view of personification of preventive therapy in accordance with modern treatment standards. The efficacy and safety of oral anticoagulant therapy has been reviewed in terms of the net clinical benefit. Particular attention is paid to the age-related aspects of choosing an anticoagulant for indefinite prophylaxis; an assessment of anticoagulants is presented in accordance with the FORTA concept, which regulates the use of drugs in elderly patients. In conclusion, recommendations are formulated for the choice of an anticoagulant in patients with atrial fibrillation in the most common clinical situations. As a general rule, the choice of a particular drug should be individualized based on risk factors, tolerability, net clinical benefit, patient preference, potential adverse interactions, and other clinical characteristics.
format	article
author	Marina Yu. Maksimova Andrei V. Fonyakin Liudmila A. Geraskina
author_facet	Marina Yu. Maksimova Andrei V. Fonyakin Liudmila A. Geraskina
author_sort	Marina Yu. Maksimova
title	Prevention of ischemic stroke in atrial fibrillation from the point of view of a neurologist. Standards and real clinical practice
title_short	Prevention of ischemic stroke in atrial fibrillation from the point of view of a neurologist. Standards and real clinical practice
title_full	Prevention of ischemic stroke in atrial fibrillation from the point of view of a neurologist. Standards and real clinical practice
title_fullStr	Prevention of ischemic stroke in atrial fibrillation from the point of view of a neurologist. Standards and real clinical practice
title_full_unstemmed	Prevention of ischemic stroke in atrial fibrillation from the point of view of a neurologist. Standards and real clinical practice
title_sort	prevention of ischemic stroke in atrial fibrillation from the point of view of a neurologist. standards and real clinical practice
publisher	"Consilium Medicum" Publishing house
publishDate	2021
url	https://doaj.org/article/286137aa30ec4ae78394a2f3330bed9d
work_keys_str_mv	AT marinayumaksimova preventionofischemicstrokeinatrialfibrillationfromthepointofviewofaneurologiststandardsandrealclinicalpractice AT andreivfonyakin preventionofischemicstrokeinatrialfibrillationfromthepointofviewofaneurologiststandardsandrealclinicalpractice AT liudmilaageraskina preventionofischemicstrokeinatrialfibrillationfromthepointofviewofaneurologiststandardsandrealclinicalpractice
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Prevention of ischemic stroke in atrial fibrillation from the point of view of a neurologist. Standards and real clinical practice

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