Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study

Abstract Background Some studies previously demonstrated that interleukin-17 (IL-17) involves in pulmonary diseases progression. Nevertheless, the role of IL-17 in community-acquired pneumonia (CAP) remains unknown. This study aims to examine the correlations between serum IL-17 with the severity an...

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Autores principales:	Chun-Mei Feng, Xin-Ming Wang, Meng-Die Li, Zheng Xu, Dong-Xu Hua, Jia-Yi Cheng, Ling Zheng, Hui Zhao, Lin Fu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Community-acquired pneumonia Interleukin-17 CAP severity scores Prognosis Biomarker Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/2861514c82a04ae0bc008f80a1f5e49f
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spelling	oai:doaj.org-article:2861514c82a04ae0bc008f80a1f5e49f2021-12-05T12:23:24ZSerum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study10.1186/s12890-021-01770-61471-2466https://doaj.org/article/2861514c82a04ae0bc008f80a1f5e49f2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12890-021-01770-6https://doaj.org/toc/1471-2466Abstract Background Some studies previously demonstrated that interleukin-17 (IL-17) involves in pulmonary diseases progression. Nevertheless, the role of IL-17 in community-acquired pneumonia (CAP) remains unknown. This study aims to examine the correlations between serum IL-17 with the severity and prognosis in CAP patients through a prospective cohort study. Methods All 239 CAP patients were recruited. Serum IL-17 was detected by enzyme-linked immunosorbent assay (ELISA). The CAP severity was evaluated through CAP severity scores, including CURB-65, CRB-65, PSI, SMART-COP, CURXO and APACHE II. Results Serum IL-17 was gradually increased consistent with the severity of CAP. Correlative analysis suggested that serum IL-17 was associated with clinical physiologic indicators among CAP patients. Logistic regression indicated that serum IL-17 was positively related to CAP severity scores. Additionally, the prognostic outcomes were tracked among CAP patients. The levels of IL-17 on admission were significantly increased in CAP patients with ICU admission, mechanical ventilation, vasoactive agent, death and longer hospitalization days. Logistic regression analyses revealed serum higher IL-17 on admission elevated the risks of vasoactive agent usage and longer hospital stays in CAP patients. The cut-off concentrations of serum IL-17 for death, ICU admission, mechanical ventilation and ≥ 14 hospital stays were 86.80 ng/mL, 84.92 ng/mL, 84.92 ng/mL and 60.29 ng/mL respectively. Conclusions Serum IL-17 on admission is positively associated with the severity and poor prognosis among CAP patients, revealing that IL-17 may implicate in the pathological process of CAP. Therefore, serum IL-17 may become an effective biomarker for diagnosis, prognosis and therapy for CAP patients.Chun-Mei FengXin-Ming WangMeng-Die LiZheng XuDong-Xu HuaJia-Yi ChengLing ZhengHui ZhaoLin FuBMCarticleCommunity-acquired pneumoniaInterleukin-17CAP severity scoresPrognosisBiomarkerDiseases of the respiratory systemRC705-779ENBMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Community-acquired pneumonia Interleukin-17 CAP severity scores Prognosis Biomarker Diseases of the respiratory system RC705-779
spellingShingle	Community-acquired pneumonia Interleukin-17 CAP severity scores Prognosis Biomarker Diseases of the respiratory system RC705-779 Chun-Mei Feng Xin-Ming Wang Meng-Die Li Zheng Xu Dong-Xu Hua Jia-Yi Cheng Ling Zheng Hui Zhao Lin Fu Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study
description	Abstract Background Some studies previously demonstrated that interleukin-17 (IL-17) involves in pulmonary diseases progression. Nevertheless, the role of IL-17 in community-acquired pneumonia (CAP) remains unknown. This study aims to examine the correlations between serum IL-17 with the severity and prognosis in CAP patients through a prospective cohort study. Methods All 239 CAP patients were recruited. Serum IL-17 was detected by enzyme-linked immunosorbent assay (ELISA). The CAP severity was evaluated through CAP severity scores, including CURB-65, CRB-65, PSI, SMART-COP, CURXO and APACHE II. Results Serum IL-17 was gradually increased consistent with the severity of CAP. Correlative analysis suggested that serum IL-17 was associated with clinical physiologic indicators among CAP patients. Logistic regression indicated that serum IL-17 was positively related to CAP severity scores. Additionally, the prognostic outcomes were tracked among CAP patients. The levels of IL-17 on admission were significantly increased in CAP patients with ICU admission, mechanical ventilation, vasoactive agent, death and longer hospitalization days. Logistic regression analyses revealed serum higher IL-17 on admission elevated the risks of vasoactive agent usage and longer hospital stays in CAP patients. The cut-off concentrations of serum IL-17 for death, ICU admission, mechanical ventilation and ≥ 14 hospital stays were 86.80 ng/mL, 84.92 ng/mL, 84.92 ng/mL and 60.29 ng/mL respectively. Conclusions Serum IL-17 on admission is positively associated with the severity and poor prognosis among CAP patients, revealing that IL-17 may implicate in the pathological process of CAP. Therefore, serum IL-17 may become an effective biomarker for diagnosis, prognosis and therapy for CAP patients.
format	article
author	Chun-Mei Feng Xin-Ming Wang Meng-Die Li Zheng Xu Dong-Xu Hua Jia-Yi Cheng Ling Zheng Hui Zhao Lin Fu
author_facet	Chun-Mei Feng Xin-Ming Wang Meng-Die Li Zheng Xu Dong-Xu Hua Jia-Yi Cheng Ling Zheng Hui Zhao Lin Fu
author_sort	Chun-Mei Feng
title	Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study
title_short	Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study
title_full	Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study
title_fullStr	Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study
title_full_unstemmed	Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study
title_sort	serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/2861514c82a04ae0bc008f80a1f5e49f
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Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study

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