Stem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?

Hundreds of thousands of people suffer spinal cord injuries each year. The experimental application of stem cells following spinal cord injury has opened a new era to promote neuroprotection and neuroregeneration of damaged tissue. Currently, there is great interest in the intravenous administration...

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Autores principales:	Krisztián Pajer, Tamás Bellák, Antal Nógrádi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	spinal cord injury secretome lesion-induced secretome mesenchymal stem cells neural stem cells induced pluripotent stem cells Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/28646f748099422884a127364368c986
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spelling	oai:doaj.org-article:28646f748099422884a127364368c9862021-11-25T17:12:57ZStem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?10.3390/cells101132142073-4409https://doaj.org/article/28646f748099422884a127364368c9862021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3214https://doaj.org/toc/2073-4409Hundreds of thousands of people suffer spinal cord injuries each year. The experimental application of stem cells following spinal cord injury has opened a new era to promote neuroprotection and neuroregeneration of damaged tissue. Currently, there is great interest in the intravenous administration of the secretome produced by mesenchymal stem cells in acute or subacute spinal cord injuries. However, it is important to highlight that undifferentiated neural stem cells and induced pluripotent stem cells are able to adapt to the damaged environment and produce the so-called lesion-induced secretome. This review article focuses on current research related to the secretome and the lesion-induced secretome and their roles in modulating spinal cord injury symptoms and functional recovery, emphasizing different compositions of the lesion-induced secretome in various models of spinal cord injury.Krisztián PajerTamás BellákAntal NógrádiMDPI AGarticlespinal cord injurysecretomelesion-induced secretomemesenchymal stem cellsneural stem cellsinduced pluripotent stem cellsBiology (General)QH301-705.5ENCells, Vol 10, Iss 3214, p 3214 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spinal cord injury secretome lesion-induced secretome mesenchymal stem cells neural stem cells induced pluripotent stem cells Biology (General) QH301-705.5
spellingShingle	spinal cord injury secretome lesion-induced secretome mesenchymal stem cells neural stem cells induced pluripotent stem cells Biology (General) QH301-705.5 Krisztián Pajer Tamás Bellák Antal Nógrádi Stem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?
description	Hundreds of thousands of people suffer spinal cord injuries each year. The experimental application of stem cells following spinal cord injury has opened a new era to promote neuroprotection and neuroregeneration of damaged tissue. Currently, there is great interest in the intravenous administration of the secretome produced by mesenchymal stem cells in acute or subacute spinal cord injuries. However, it is important to highlight that undifferentiated neural stem cells and induced pluripotent stem cells are able to adapt to the damaged environment and produce the so-called lesion-induced secretome. This review article focuses on current research related to the secretome and the lesion-induced secretome and their roles in modulating spinal cord injury symptoms and functional recovery, emphasizing different compositions of the lesion-induced secretome in various models of spinal cord injury.
format	article
author	Krisztián Pajer Tamás Bellák Antal Nógrádi
author_facet	Krisztián Pajer Tamás Bellák Antal Nógrádi
author_sort	Krisztián Pajer
title	Stem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?
title_short	Stem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?
title_full	Stem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?
title_fullStr	Stem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?
title_full_unstemmed	Stem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?
title_sort	stem cell secretome for spinal cord repair: is it more than just a random baseline set of factors?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/28646f748099422884a127364368c986
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Stem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?

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