Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture

Despite the identification of genetic risk loci for late-onset Alzheimer’s disease (LOAD), the genetic architecture and prediction remains unclear. Here, the authors use genetic risk scores for prediction of LOAD across three datasets and show evidence suggesting oligogenic variant architecture for...

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Autores principales:	Qian Zhang, Julia Sidorenko, Baptiste Couvy-Duchesne, Riccardo E. Marioni, Margaret J. Wright, Alison M. Goate, Edoardo Marcora, Kuan-lin Huang, Tenielle Porter, Simon M. Laws, Australian Imaging Biomarkers and Lifestyle (AIBL) Study, Perminder S. Sachdev, Karen A. Mather, Nicola J. Armstrong, Anbupalam Thalamuthu, Henry Brodaty, Loic Yengo, Jian Yang, Naomi R. Wray, Allan F. McRae, Peter M. Visscher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2864aaa787e447968771d91143faf890
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spelling	oai:doaj.org-article:2864aaa787e447968771d91143faf8902021-12-02T18:48:25ZRisk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture10.1038/s41467-020-18534-12041-1723https://doaj.org/article/2864aaa787e447968771d91143faf8902020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18534-1https://doaj.org/toc/2041-1723Despite the identification of genetic risk loci for late-onset Alzheimer’s disease (LOAD), the genetic architecture and prediction remains unclear. Here, the authors use genetic risk scores for prediction of LOAD across three datasets and show evidence suggesting oligogenic variant architecture for this disease.Qian ZhangJulia SidorenkoBaptiste Couvy-DuchesneRiccardo E. MarioniMargaret J. WrightAlison M. GoateEdoardo MarcoraKuan-lin HuangTenielle PorterSimon M. LawsAustralian Imaging Biomarkers and Lifestyle (AIBL) StudyPerminder S. SachdevKaren A. MatherNicola J. ArmstrongAnbupalam ThalamuthuHenry BrodatyLoic YengoJian YangNaomi R. WrayAllan F. McRaePeter M. VisscherNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian Zhang Julia Sidorenko Baptiste Couvy-Duchesne Riccardo E. Marioni Margaret J. Wright Alison M. Goate Edoardo Marcora Kuan-lin Huang Tenielle Porter Simon M. Laws Australian Imaging Biomarkers and Lifestyle (AIBL) Study Perminder S. Sachdev Karen A. Mather Nicola J. Armstrong Anbupalam Thalamuthu Henry Brodaty Loic Yengo Jian Yang Naomi R. Wray Allan F. McRae Peter M. Visscher Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
description	Despite the identification of genetic risk loci for late-onset Alzheimer’s disease (LOAD), the genetic architecture and prediction remains unclear. Here, the authors use genetic risk scores for prediction of LOAD across three datasets and show evidence suggesting oligogenic variant architecture for this disease.
format	article
author	Qian Zhang Julia Sidorenko Baptiste Couvy-Duchesne Riccardo E. Marioni Margaret J. Wright Alison M. Goate Edoardo Marcora Kuan-lin Huang Tenielle Porter Simon M. Laws Australian Imaging Biomarkers and Lifestyle (AIBL) Study Perminder S. Sachdev Karen A. Mather Nicola J. Armstrong Anbupalam Thalamuthu Henry Brodaty Loic Yengo Jian Yang Naomi R. Wray Allan F. McRae Peter M. Visscher
author_facet	Qian Zhang Julia Sidorenko Baptiste Couvy-Duchesne Riccardo E. Marioni Margaret J. Wright Alison M. Goate Edoardo Marcora Kuan-lin Huang Tenielle Porter Simon M. Laws Australian Imaging Biomarkers and Lifestyle (AIBL) Study Perminder S. Sachdev Karen A. Mather Nicola J. Armstrong Anbupalam Thalamuthu Henry Brodaty Loic Yengo Jian Yang Naomi R. Wray Allan F. McRae Peter M. Visscher
author_sort	Qian Zhang
title	Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
title_short	Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
title_full	Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
title_fullStr	Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
title_full_unstemmed	Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
title_sort	risk prediction of late-onset alzheimer’s disease implies an oligogenic architecture
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2864aaa787e447968771d91143faf890
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Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture

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