Key role of quinone in the mechanism of respiratory complex I

Complex I (NADH:ubiquinone oxidoreductase) is the first enzyme of the respiratory chain in bacteria and mitochondria. Here, the authors present cryo-EM and crystal structures of T. thermophilus complex I in different conformational states and further analyse them by Normal Mode Analysis and molecula...

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Auteurs principaux:	Javier Gutiérrez-Fernández, Karol Kaszuba, Gurdeep S. Minhas, Rozbeh Baradaran, Margherita Tambalo, David T. Gallagher, Leonid A. Sazanov
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/2865989836bc44c684807dba957f46af
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spelling	oai:doaj.org-article:2865989836bc44c684807dba957f46af2021-12-02T18:00:10ZKey role of quinone in the mechanism of respiratory complex I10.1038/s41467-020-17957-02041-1723https://doaj.org/article/2865989836bc44c684807dba957f46af2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17957-0https://doaj.org/toc/2041-1723Complex I (NADH:ubiquinone oxidoreductase) is the first enzyme of the respiratory chain in bacteria and mitochondria. Here, the authors present cryo-EM and crystal structures of T. thermophilus complex I in different conformational states and further analyse them by Normal Mode Analysis and molecular dynamics simulations and conclude that quinone redox reactions are important for the coupling mechanism of complex I.Javier Gutiérrez-FernándezKarol KaszubaGurdeep S. MinhasRozbeh BaradaranMargherita TambaloDavid T. GallagherLeonid A. SazanovNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Javier Gutiérrez-Fernández Karol Kaszuba Gurdeep S. Minhas Rozbeh Baradaran Margherita Tambalo David T. Gallagher Leonid A. Sazanov Key role of quinone in the mechanism of respiratory complex I
description	Complex I (NADH:ubiquinone oxidoreductase) is the first enzyme of the respiratory chain in bacteria and mitochondria. Here, the authors present cryo-EM and crystal structures of T. thermophilus complex I in different conformational states and further analyse them by Normal Mode Analysis and molecular dynamics simulations and conclude that quinone redox reactions are important for the coupling mechanism of complex I.
format	article
author	Javier Gutiérrez-Fernández Karol Kaszuba Gurdeep S. Minhas Rozbeh Baradaran Margherita Tambalo David T. Gallagher Leonid A. Sazanov
author_facet	Javier Gutiérrez-Fernández Karol Kaszuba Gurdeep S. Minhas Rozbeh Baradaran Margherita Tambalo David T. Gallagher Leonid A. Sazanov
author_sort	Javier Gutiérrez-Fernández
title	Key role of quinone in the mechanism of respiratory complex I
title_short	Key role of quinone in the mechanism of respiratory complex I
title_full	Key role of quinone in the mechanism of respiratory complex I
title_fullStr	Key role of quinone in the mechanism of respiratory complex I
title_full_unstemmed	Key role of quinone in the mechanism of respiratory complex I
title_sort	key role of quinone in the mechanism of respiratory complex i
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2865989836bc44c684807dba957f46af
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Key role of quinone in the mechanism of respiratory complex I

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