Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride
Abstract Enabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the inco...
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Nature Portfolio
2017
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oai:doaj.org-article:286685f8209d4c12be0eedc90a5b6a802021-12-02T12:32:21ZFacile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride10.1038/s41598-017-04643-32045-2322https://doaj.org/article/286685f8209d4c12be0eedc90a5b6a802017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04643-3https://doaj.org/toc/2045-2322Abstract Enabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the incorporation of large complex molecules will allow a functionalization strategy for the next generation of biomaterial engineering. Here, for the first time, we show that co-assembly with increasing concentrations of a highly charged polysaccharide, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical properties of the resultant hydrogel can be easily and effectively manipulated without disruption to the nanofibrillar structure of the assembly.Rui LiMitchell Boyd-MossBenjamin LongAnne MartelAndrew ParnellAndrew J. C. DennisonColin J. BarrowDavid R. NisbetRichard J. WilliamsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Rui Li Mitchell Boyd-Moss Benjamin Long Anne Martel Andrew Parnell Andrew J. C. Dennison Colin J. Barrow David R. Nisbet Richard J. Williams Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride |
| description |
Abstract Enabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the incorporation of large complex molecules will allow a functionalization strategy for the next generation of biomaterial engineering. Here, for the first time, we show that co-assembly with increasing concentrations of a highly charged polysaccharide, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical properties of the resultant hydrogel can be easily and effectively manipulated without disruption to the nanofibrillar structure of the assembly. |
| format |
article |
| author |
Rui Li Mitchell Boyd-Moss Benjamin Long Anne Martel Andrew Parnell Andrew J. C. Dennison Colin J. Barrow David R. Nisbet Richard J. Williams |
| author_facet |
Rui Li Mitchell Boyd-Moss Benjamin Long Anne Martel Andrew Parnell Andrew J. C. Dennison Colin J. Barrow David R. Nisbet Richard J. Williams |
| author_sort |
Rui Li |
| title |
Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride |
| title_short |
Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride |
| title_full |
Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride |
| title_fullStr |
Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride |
| title_full_unstemmed |
Facile Control over the Supramolecular Ordering of Self-assembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride |
| title_sort |
facile control over the supramolecular ordering of self-assembled peptide scaffolds by simultaneous assembly with a polysacharride |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/286685f8209d4c12be0eedc90a5b6a80 |
| work_keys_str_mv |
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1718394085089214464 |