Antibacterial and Anticancer Potentials of Presynthesized Photosensitive Plectranthus cylindraceus Oil/TiO2/Polyethylene Glycol Polymeric Bionanocomposite

The present study is concerned with the fabrication of the bifunctional Plectranthus cylindraceus oil/TiO2/polyethylene glycol polymeric film for antibacterial and anticancer activities. The suggested film is based on the utility of naturally extracted P. cylindraceus oil in the formation of the pol...

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Autores principales:	Musarat Amina, Nawal M. Al Musayeib, Nawal A. Alarfaj, Maha F. El-Tohamy, Gadah A. Al-Hamoud
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Biotechnology TP248.13-248.65 Inorganic chemistry QD146-197
Acceso en línea:	https://doaj.org/article/2868135ec9de416cb7110b4c600709f5
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spelling	oai:doaj.org-article:2868135ec9de416cb7110b4c600709f52021-11-08T02:37:03ZAntibacterial and Anticancer Potentials of Presynthesized Photosensitive Plectranthus cylindraceus Oil/TiO2/Polyethylene Glycol Polymeric Bionanocomposite1687-479X10.1155/2021/5562206https://doaj.org/article/2868135ec9de416cb7110b4c600709f52021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5562206https://doaj.org/toc/1687-479XThe present study is concerned with the fabrication of the bifunctional Plectranthus cylindraceus oil/TiO2/polyethylene glycol polymeric film for antibacterial and anticancer activities. The suggested film is based on the utility of naturally extracted P. cylindraceus oil in the formation of the polymeric bionanocomposite film decorated with TiO2 nanoparticles. The bionanocomposite film was fabricated by incorporating 15 w% of P. cylindraceus oil with 10 w% polyethylene glycol and 5 w% TiO2 nanoparticles. The active components of P. cylindraceus oil were verified using gas chromatography coupled with mass spectrometry (GC-MS). The surface morphology of the resulted bionanocomposite film was characterized by various spectroscopic and microscopic techniques. The antibacterial potential of the fabricated bionanocomposite film was investigated against four pathogenic strains. The obtained results revealed excellent sensitivity against the bacterial strains, particularly E. coli and S. aureus, with minimum inhibitory concentration 320 µg mL−1 and minimum bactericidal concentration 640 and 1280 µg mL−1 for E. coli and S. aureus, respectively. Polymeric bionanocomposite exerted significant cytotoxicity against human lung carcinoma cell lines in a concentration-dependent manner with an IC50 value of 42.7 ± 0.25 μg mL−1. Safety assessment test against peripheral blood mononuclear cells (PBMCs) demonstrated that the bionanocomposite is nontoxic in nature. Bionanocomposite also showed potent photocatalytic effects. Overall, the results concluded that the bionanocomposite has expressed scope for multifaceted biomedical applications.Musarat AminaNawal M. Al MusayeibNawal A. AlarfajMaha F. El-TohamyGadah A. Al-HamoudHindawi LimitedarticleBiotechnologyTP248.13-248.65Inorganic chemistryQD146-197ENBioinorganic Chemistry and Applications, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Inorganic chemistry QD146-197
spellingShingle	Biotechnology TP248.13-248.65 Inorganic chemistry QD146-197 Musarat Amina Nawal M. Al Musayeib Nawal A. Alarfaj Maha F. El-Tohamy Gadah A. Al-Hamoud Antibacterial and Anticancer Potentials of Presynthesized Photosensitive Plectranthus cylindraceus Oil/TiO2/Polyethylene Glycol Polymeric Bionanocomposite
description	The present study is concerned with the fabrication of the bifunctional Plectranthus cylindraceus oil/TiO2/polyethylene glycol polymeric film for antibacterial and anticancer activities. The suggested film is based on the utility of naturally extracted P. cylindraceus oil in the formation of the polymeric bionanocomposite film decorated with TiO2 nanoparticles. The bionanocomposite film was fabricated by incorporating 15 w% of P. cylindraceus oil with 10 w% polyethylene glycol and 5 w% TiO2 nanoparticles. The active components of P. cylindraceus oil were verified using gas chromatography coupled with mass spectrometry (GC-MS). The surface morphology of the resulted bionanocomposite film was characterized by various spectroscopic and microscopic techniques. The antibacterial potential of the fabricated bionanocomposite film was investigated against four pathogenic strains. The obtained results revealed excellent sensitivity against the bacterial strains, particularly E. coli and S. aureus, with minimum inhibitory concentration 320 µg mL−1 and minimum bactericidal concentration 640 and 1280 µg mL−1 for E. coli and S. aureus, respectively. Polymeric bionanocomposite exerted significant cytotoxicity against human lung carcinoma cell lines in a concentration-dependent manner with an IC50 value of 42.7 ± 0.25 μg mL−1. Safety assessment test against peripheral blood mononuclear cells (PBMCs) demonstrated that the bionanocomposite is nontoxic in nature. Bionanocomposite also showed potent photocatalytic effects. Overall, the results concluded that the bionanocomposite has expressed scope for multifaceted biomedical applications.
format	article
author	Musarat Amina Nawal M. Al Musayeib Nawal A. Alarfaj Maha F. El-Tohamy Gadah A. Al-Hamoud
author_facet	Musarat Amina Nawal M. Al Musayeib Nawal A. Alarfaj Maha F. El-Tohamy Gadah A. Al-Hamoud
author_sort	Musarat Amina
title	Antibacterial and Anticancer Potentials of Presynthesized Photosensitive Plectranthus cylindraceus Oil/TiO2/Polyethylene Glycol Polymeric Bionanocomposite
title_short	Antibacterial and Anticancer Potentials of Presynthesized Photosensitive Plectranthus cylindraceus Oil/TiO2/Polyethylene Glycol Polymeric Bionanocomposite
title_full	Antibacterial and Anticancer Potentials of Presynthesized Photosensitive Plectranthus cylindraceus Oil/TiO2/Polyethylene Glycol Polymeric Bionanocomposite
title_fullStr	Antibacterial and Anticancer Potentials of Presynthesized Photosensitive Plectranthus cylindraceus Oil/TiO2/Polyethylene Glycol Polymeric Bionanocomposite
title_full_unstemmed	Antibacterial and Anticancer Potentials of Presynthesized Photosensitive Plectranthus cylindraceus Oil/TiO2/Polyethylene Glycol Polymeric Bionanocomposite
title_sort	antibacterial and anticancer potentials of presynthesized photosensitive plectranthus cylindraceus oil/tio2/polyethylene glycol polymeric bionanocomposite
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/2868135ec9de416cb7110b4c600709f5
work_keys_str_mv	AT musaratamina antibacterialandanticancerpotentialsofpresynthesizedphotosensitiveplectranthuscylindraceusoiltio2polyethyleneglycolpolymericbionanocomposite AT nawalmalmusayeib antibacterialandanticancerpotentialsofpresynthesizedphotosensitiveplectranthuscylindraceusoiltio2polyethyleneglycolpolymericbionanocomposite AT nawalaalarfaj antibacterialandanticancerpotentialsofpresynthesizedphotosensitiveplectranthuscylindraceusoiltio2polyethyleneglycolpolymericbionanocomposite AT mahafeltohamy antibacterialandanticancerpotentialsofpresynthesizedphotosensitiveplectranthuscylindraceusoiltio2polyethyleneglycolpolymericbionanocomposite AT gadahaalhamoud antibacterialandanticancerpotentialsofpresynthesizedphotosensitiveplectranthuscylindraceusoiltio2polyethyleneglycolpolymericbionanocomposite
_version_	1718442983712358400

Antibacterial and Anticancer Potentials of Presynthesized Photosensitive Plectranthus cylindraceus Oil/TiO2/Polyethylene Glycol Polymeric Bionanocomposite

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