Long-Term Safety and Efficacy of Siluron2000 with Pars Plana Vitrectomy in the Treatment of Patients with Severe Vitreoretinopathy and Chronic Macular Holes

Parnian Arjmand,1,2 Tina Felfeli,1,3,4 Efrem D Mandelcorn,1,2,4 Mark S Mandelcorn1,2,4 1Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada; 2Department of Ophthalmology, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; 3The...

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Autores principales:	Arjmand P, Felfeli T, Mandelcorn ED, Mandelcorn MS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	emulsification proliferative vitreoretinopathy silicone oil tamponade vitreoretinal surgery long-term oi Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/286d0b00ab564ff3bb1236e7f9bfbb1a
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spelling	oai:doaj.org-article:286d0b00ab564ff3bb1236e7f9bfbb1a2021-12-02T17:54:55ZLong-Term Safety and Efficacy of Siluron2000 with Pars Plana Vitrectomy in the Treatment of Patients with Severe Vitreoretinopathy and Chronic Macular Holes1177-5483https://doaj.org/article/286d0b00ab564ff3bb1236e7f9bfbb1a2021-11-01T00:00:00Zhttps://www.dovepress.com/long-term-safety-and-efficacy-of-siluron2000-with-pars-plana-vitrectom-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Parnian Arjmand,1,2 Tina Felfeli,1,3,4 Efrem D Mandelcorn,1,2,4 Mark S Mandelcorn1,2,4 1Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada; 2Department of Ophthalmology, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; 3The Institute of Health Policy, Management and Evaluation (IHPME), Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; 4Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaCorrespondence: Mark S Mandelcorn Tel +1 416 603 5885Fax +1 416 603 5834Email mark.mandelcorn@utoronto.caPurpose: Silicone oil intraocular retinal tamponade is a useful adjunct to pars plana vitrectomy (PPV) in the treatment of complex vitreoretinal conditions. Siluron2000, a modified silicone oil product containing an additional small, high molecular weight and low viscosity, very-long-chain silicone molecule, was developed to reduce post-operative silicone oil emulsification, a non-infrequent complication that occurs with low molecular weight silicone oil. This study was designed to assess the safety and efficacy of long-term Siluron2000.Patients and Methods: This was a single-center, retrospective, observational study. All consecutive patients undergoing PPV with intravitreal Siluron2000 injection between January 2017 and September 2019 with at least 6-month follow-up were identified based on billing codes.Results: A total of 57 eyes of 57 consecutive patients comprising 51 cases of proliferative vitreoretinopathy and 6 cases of recurrent full thickness macular hole were included. Median follow-up was 18 months. Emulsification occurred in 9 patients (15%). Retinal re-attachment was achieved in 47 patients (82%). The median time without silicone oil emulsification was 17 months. Of the cases with residual retinal detachment (RD) despite intravitreal Siluron2000, 4 (7%) were total RDs and 6 (10%) were inferior RDs with attached macula. The most common complications were glaucoma 12 (21%), cataract 11 (19%), and epiretinal membrane 2 (3.5%). There was no association between the duration of Siluron2000 and visual outcomes.Conclusion: Siluron2000 is an effective long-term tamponade agent in the treatment of complex vitreoretinopathy. Visual and anatomical outcomes are similar to those reported with higher mw silicone oil tamponade agents but with a lower emulsification rate.Keywords: emulsification, proliferative vitreoretinopathy, silicone oil, tamponade, vitreoretinal surgery, long-term oilArjmand PFelfeli TMandelcorn EDMandelcorn MSDove Medical Pressarticleemulsificationproliferative vitreoretinopathysilicone oiltamponadevitreoretinal surgerylong-term oiOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 4373-4379 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	emulsification proliferative vitreoretinopathy silicone oil tamponade vitreoretinal surgery long-term oi Ophthalmology RE1-994
spellingShingle	emulsification proliferative vitreoretinopathy silicone oil tamponade vitreoretinal surgery long-term oi Ophthalmology RE1-994 Arjmand P Felfeli T Mandelcorn ED Mandelcorn MS Long-Term Safety and Efficacy of Siluron2000 with Pars Plana Vitrectomy in the Treatment of Patients with Severe Vitreoretinopathy and Chronic Macular Holes
description	Parnian Arjmand,1,2 Tina Felfeli,1,3,4 Efrem D Mandelcorn,1,2,4 Mark S Mandelcorn1,2,4 1Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada; 2Department of Ophthalmology, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; 3The Institute of Health Policy, Management and Evaluation (IHPME), Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; 4Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaCorrespondence: Mark S Mandelcorn Tel +1 416 603 5885Fax +1 416 603 5834Email mark.mandelcorn@utoronto.caPurpose: Silicone oil intraocular retinal tamponade is a useful adjunct to pars plana vitrectomy (PPV) in the treatment of complex vitreoretinal conditions. Siluron2000, a modified silicone oil product containing an additional small, high molecular weight and low viscosity, very-long-chain silicone molecule, was developed to reduce post-operative silicone oil emulsification, a non-infrequent complication that occurs with low molecular weight silicone oil. This study was designed to assess the safety and efficacy of long-term Siluron2000.Patients and Methods: This was a single-center, retrospective, observational study. All consecutive patients undergoing PPV with intravitreal Siluron2000 injection between January 2017 and September 2019 with at least 6-month follow-up were identified based on billing codes.Results: A total of 57 eyes of 57 consecutive patients comprising 51 cases of proliferative vitreoretinopathy and 6 cases of recurrent full thickness macular hole were included. Median follow-up was 18 months. Emulsification occurred in 9 patients (15%). Retinal re-attachment was achieved in 47 patients (82%). The median time without silicone oil emulsification was 17 months. Of the cases with residual retinal detachment (RD) despite intravitreal Siluron2000, 4 (7%) were total RDs and 6 (10%) were inferior RDs with attached macula. The most common complications were glaucoma 12 (21%), cataract 11 (19%), and epiretinal membrane 2 (3.5%). There was no association between the duration of Siluron2000 and visual outcomes.Conclusion: Siluron2000 is an effective long-term tamponade agent in the treatment of complex vitreoretinopathy. Visual and anatomical outcomes are similar to those reported with higher mw silicone oil tamponade agents but with a lower emulsification rate.Keywords: emulsification, proliferative vitreoretinopathy, silicone oil, tamponade, vitreoretinal surgery, long-term oil
format	article
author	Arjmand P Felfeli T Mandelcorn ED Mandelcorn MS
author_facet	Arjmand P Felfeli T Mandelcorn ED Mandelcorn MS
author_sort	Arjmand P
title	Long-Term Safety and Efficacy of Siluron2000 with Pars Plana Vitrectomy in the Treatment of Patients with Severe Vitreoretinopathy and Chronic Macular Holes
title_short	Long-Term Safety and Efficacy of Siluron2000 with Pars Plana Vitrectomy in the Treatment of Patients with Severe Vitreoretinopathy and Chronic Macular Holes
title_full	Long-Term Safety and Efficacy of Siluron2000 with Pars Plana Vitrectomy in the Treatment of Patients with Severe Vitreoretinopathy and Chronic Macular Holes
title_fullStr	Long-Term Safety and Efficacy of Siluron2000 with Pars Plana Vitrectomy in the Treatment of Patients with Severe Vitreoretinopathy and Chronic Macular Holes
title_full_unstemmed	Long-Term Safety and Efficacy of Siluron2000 with Pars Plana Vitrectomy in the Treatment of Patients with Severe Vitreoretinopathy and Chronic Macular Holes
title_sort	long-term safety and efficacy of siluron2000 with pars plana vitrectomy in the treatment of patients with severe vitreoretinopathy and chronic macular holes
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/286d0b00ab564ff3bb1236e7f9bfbb1a
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Long-Term Safety and Efficacy of Siluron2000 with Pars Plana Vitrectomy in the Treatment of Patients with Severe Vitreoretinopathy and Chronic Macular Holes

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