Metabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD)

Nonalcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that was first described in 1980. It has been prevalent and on the rise for many years and is associated with other metabolic disorders such as obesity and type 2 diabetes mellitus (T2DM). NAFLD can be best described as...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Paria Zarghamravanbakhsh, Michael Frenkel, Leonid Poretsky
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Physiology QP1-981 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/2871377fe0d942d5b641f72654a13608
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2871377fe0d942d5b641f72654a13608
record_format	dspace
spelling	oai:doaj.org-article:2871377fe0d942d5b641f72654a136082021-11-24T04:33:45ZMetabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD)2589-936810.1016/j.metop.2021.100149https://doaj.org/article/2871377fe0d942d5b641f72654a136082021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589936821000736https://doaj.org/toc/2589-9368Nonalcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that was first described in 1980. It has been prevalent and on the rise for many years and is associated with other metabolic disorders such as obesity and type 2 diabetes mellitus (T2DM). NAFLD can be best described as a metabolic dysfunction that stems from insulin resistance-induced hepatic lipogenesis. This lipogenesis increases oxidative stress and hepatic inflammation and is often potentiated by genetic and gut microbiome dysfunction. As NAFLD progresses from simple steatosis to non-alcoholic steatohepatitis (NASH) and to cirrhosis and hepatocellular carcinoma (HCC), the odds of complications including cardiovascular disease (CVD), chronic kidney disease (CKD), and overall mortality increase. The aim of this review is to describe the metabolic causes and consequences of NAFLD while examining the risks that each stage of NAFLD poses. In this review, the etiology of “lean” NAFLD, the impact of obesity, T2DM, genetics, and microbiome dysbiosis on NAFLD progression are all explored. This review will also discuss the core issue behind the progression of NAFLD: insulin resistance (IR). Upon describing the causes and consequences of NAFLD, the effectiveness of diet modification, lifestyle changes, and glucagon-like peptide 1 receptor (GLP-1) agonists to retard NAFLD progression and stem the rate of complications is examined.Paria ZarghamravanbakhshMichael FrenkelLeonid PoretskyElsevierarticlePhysiologyQP1-981BiochemistryQD415-436ENMetabolism Open, Vol 12, Iss , Pp 100149- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Physiology QP1-981 Biochemistry QD415-436
spellingShingle	Physiology QP1-981 Biochemistry QD415-436 Paria Zarghamravanbakhsh Michael Frenkel Leonid Poretsky Metabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD)
description	Nonalcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that was first described in 1980. It has been prevalent and on the rise for many years and is associated with other metabolic disorders such as obesity and type 2 diabetes mellitus (T2DM). NAFLD can be best described as a metabolic dysfunction that stems from insulin resistance-induced hepatic lipogenesis. This lipogenesis increases oxidative stress and hepatic inflammation and is often potentiated by genetic and gut microbiome dysfunction. As NAFLD progresses from simple steatosis to non-alcoholic steatohepatitis (NASH) and to cirrhosis and hepatocellular carcinoma (HCC), the odds of complications including cardiovascular disease (CVD), chronic kidney disease (CKD), and overall mortality increase. The aim of this review is to describe the metabolic causes and consequences of NAFLD while examining the risks that each stage of NAFLD poses. In this review, the etiology of “lean” NAFLD, the impact of obesity, T2DM, genetics, and microbiome dysbiosis on NAFLD progression are all explored. This review will also discuss the core issue behind the progression of NAFLD: insulin resistance (IR). Upon describing the causes and consequences of NAFLD, the effectiveness of diet modification, lifestyle changes, and glucagon-like peptide 1 receptor (GLP-1) agonists to retard NAFLD progression and stem the rate of complications is examined.
format	article
author	Paria Zarghamravanbakhsh Michael Frenkel Leonid Poretsky
author_facet	Paria Zarghamravanbakhsh Michael Frenkel Leonid Poretsky
author_sort	Paria Zarghamravanbakhsh
title	Metabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD)
title_short	Metabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD)
title_full	Metabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD)
title_fullStr	Metabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD)
title_full_unstemmed	Metabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD)
title_sort	metabolic causes and consequences of nonalcoholic fatty liver disease (nafld)
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2871377fe0d942d5b641f72654a13608
work_keys_str_mv	AT pariazarghamravanbakhsh metaboliccausesandconsequencesofnonalcoholicfattyliverdiseasenafld AT michaelfrenkel metaboliccausesandconsequencesofnonalcoholicfattyliverdiseasenafld AT leonidporetsky metaboliccausesandconsequencesofnonalcoholicfattyliverdiseasenafld
_version_	1718415903087919104

Metabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD)

Ejemplares similares