Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction

The growth-promoting activity of mTORC1 is regulated by amino acid availability via the Rag GTPases. Here, the authors demonstrate Src-dependent control of cell size and autophagy through disruption of the Rag GTPase–GATOR1 complex and mTORC1 activation at the lysosomal surface.

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Autores principales:	Rituraj Pal, Michela Palmieri, Arindam Chaudhury, Tiemo Jürgen Klisch, Alberto di Ronza, Joel R. Neilson, George G. Rodney, Marco Sardiello
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2878637528374367ad3c6859ef91cfca
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spelling	oai:doaj.org-article:2878637528374367ad3c6859ef91cfca2021-12-02T16:49:49ZSrc regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction10.1038/s41467-018-06844-42041-1723https://doaj.org/article/2878637528374367ad3c6859ef91cfca2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06844-4https://doaj.org/toc/2041-1723The growth-promoting activity of mTORC1 is regulated by amino acid availability via the Rag GTPases. Here, the authors demonstrate Src-dependent control of cell size and autophagy through disruption of the Rag GTPase–GATOR1 complex and mTORC1 activation at the lysosomal surface.Rituraj PalMichela PalmieriArindam ChaudhuryTiemo Jürgen KlischAlberto di RonzaJoel R. NeilsonGeorge G. RodneyMarco SardielloNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rituraj Pal Michela Palmieri Arindam Chaudhury Tiemo Jürgen Klisch Alberto di Ronza Joel R. Neilson George G. Rodney Marco Sardiello Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
description	The growth-promoting activity of mTORC1 is regulated by amino acid availability via the Rag GTPases. Here, the authors demonstrate Src-dependent control of cell size and autophagy through disruption of the Rag GTPase–GATOR1 complex and mTORC1 activation at the lysosomal surface.
format	article
author	Rituraj Pal Michela Palmieri Arindam Chaudhury Tiemo Jürgen Klisch Alberto di Ronza Joel R. Neilson George G. Rodney Marco Sardiello
author_facet	Rituraj Pal Michela Palmieri Arindam Chaudhury Tiemo Jürgen Klisch Alberto di Ronza Joel R. Neilson George G. Rodney Marco Sardiello
author_sort	Rituraj Pal
title	Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
title_short	Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
title_full	Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
title_fullStr	Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
title_full_unstemmed	Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
title_sort	src regulates amino acid-mediated mtorc1 activation by disrupting gator1-rag gtpase interaction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2878637528374367ad3c6859ef91cfca
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Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction

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