Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development

Roberto Cascone, Annalisa Carlucci, Matteo Pierdiluca, Mario Santini, Alfonso FiorelliThoracic Surgery Unit, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyAbstract: Soluble major histocompatibility complex cl...

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Autores principales:	Cascone R, Carlucci A, Pierdiluca M, Santini M, Fiorelli A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Non-Small Cell Lung Cancer Major Histocompatibility Complex Class I Polypeptide-Related Sequence A Major Histocompatibility Complex Class I Polypeptide-Related Sequence B prognostic factor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2883e2cd00bd40a7b7be38813d25adda
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spelling	oai:doaj.org-article:2883e2cd00bd40a7b7be38813d25adda2021-12-02T01:10:14ZPrognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development1179-2728https://doaj.org/article/2883e2cd00bd40a7b7be38813d25adda2017-10-01T00:00:00Zhttps://www.dovepress.com/prognostic-value-of-soluble-major-histocompatibility-complex-class-i-p-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728Roberto Cascone, Annalisa Carlucci, Matteo Pierdiluca, Mario Santini, Alfonso FiorelliThoracic Surgery Unit, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyAbstract: Soluble major histocompatibility complex class I polypeptide-related sequence A (sMICA) is a useful marker in surveillance of lung cancer. High serum sMICA level in patients with non-small-cell lung cancer (NSCLC) seems to be a poor prognostic factor being correlated with poor differentiation and advanced stage. However, the low specificity limits its role as a single prognostic marker of NSCLC, but its evaluation, in addition to standard serum markers, could improve the staging of NSCLC. Despite promising, all current studies are insufficient to assess the real efficiency of sMICA as a prognostic marker of NSCLC, and hence, future studies are required to validate it.Keywords: NSCLC, MICA, MICB, prognostic factor Cascone RCarlucci APierdiluca MSantini MFiorelli ADove Medical PressarticleNon-Small Cell Lung CancerMajor Histocompatibility Complex Class I Polypeptide-Related Sequence AMajor Histocompatibility Complex Class I Polypeptide-Related Sequence Bprognostic factorNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol Volume 8, Pp 161-167 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Non-Small Cell Lung Cancer Major Histocompatibility Complex Class I Polypeptide-Related Sequence A Major Histocompatibility Complex Class I Polypeptide-Related Sequence B prognostic factor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Non-Small Cell Lung Cancer Major Histocompatibility Complex Class I Polypeptide-Related Sequence A Major Histocompatibility Complex Class I Polypeptide-Related Sequence B prognostic factor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cascone R Carlucci A Pierdiluca M Santini M Fiorelli A Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
description	Roberto Cascone, Annalisa Carlucci, Matteo Pierdiluca, Mario Santini, Alfonso FiorelliThoracic Surgery Unit, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, ItalyAbstract: Soluble major histocompatibility complex class I polypeptide-related sequence A (sMICA) is a useful marker in surveillance of lung cancer. High serum sMICA level in patients with non-small-cell lung cancer (NSCLC) seems to be a poor prognostic factor being correlated with poor differentiation and advanced stage. However, the low specificity limits its role as a single prognostic marker of NSCLC, but its evaluation, in addition to standard serum markers, could improve the staging of NSCLC. Despite promising, all current studies are insufficient to assess the real efficiency of sMICA as a prognostic marker of NSCLC, and hence, future studies are required to validate it.Keywords: NSCLC, MICA, MICB, prognostic factor
format	article
author	Cascone R Carlucci A Pierdiluca M Santini M Fiorelli A
author_facet	Cascone R Carlucci A Pierdiluca M Santini M Fiorelli A
author_sort	Cascone R
title	Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
title_short	Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
title_full	Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
title_fullStr	Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
title_full_unstemmed	Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development
title_sort	prognostic value of soluble major histocompatibility complex class i polypeptide-related sequence a in non-small-cell lung cancer – significance and development
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/2883e2cd00bd40a7b7be38813d25adda
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Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer &ndash; significance and development

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Prognostic value of soluble major histocompatibility complex class I polypeptide-related sequence A in non-small-cell lung cancer – significance and development