Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing

Haruka Arai,1 Tsutomu Sakai,1 Kiichiro Okano,1 Ranko Aoyagi,1 Ayano Imai,2 Hiroshi Takase,2 Manabu Mochizuki,2 Hiroshi Tsuneoka11Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Toky...

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Autores principales:	Arai H, Sakai T, Okano K, Aoyagi R, Imai A, Takase H, Mochizuki M, Tsuneoka H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2884227b7ed34cb59168e4a010661374
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spelling	oai:doaj.org-article:2884227b7ed34cb59168e4a0106613742021-12-02T05:55:45ZPresumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing1177-5483https://doaj.org/article/2884227b7ed34cb59168e4a0106613742014-04-01T00:00:00Zhttp://www.dovepress.com/presumed-toxoplasmic-central-retinal-artery-occlusion-and-multifocal-r-a16538https://doaj.org/toc/1177-5483 Haruka Arai,1 Tsutomu Sakai,1 Kiichiro Okano,1 Ranko Aoyagi,1 Ayano Imai,2 Hiroshi Takase,2 Manabu Mochizuki,2 Hiroshi Tsuneoka11Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, JapanAbstract: Central retinal artery occlusion (CRAO) and multifocal retinitis with perivascular sheathing are rare in ocular toxoplasmosis. We report a case of toxoplasmic CRAO and multifocal retinitis with perivascular sheathing. A healthy 83-year-old male developed left panuveitis. Funduscopic examination of the left eye showed a swollen optic disc and sheathing of the retinal artery with a dense vitreous haze and a white retinal lesion. Serum anti-toxoplasma antibodies were positive in a latex agglutination assay. Vitrectomy was performed to improve visualization of the retinal lesions and for examination of causative microorganisms. A postoperative fundus examination revealed CRAO with optic disc involvement and multifocal retinitis with perivascular sheathing. Qualitative multiplex polymerase chain reaction detected the Toxoplasma gondii B1 gene in ocular fluid from both the aqueous and vitreous humor. The presumed diagnosis of ocular toxoplasmosis was made and treatment was started with prednisone and acetylspiramycin with subsequent improvement. Two months later, the patient developed active retinochoroiditis in the left eye. After 6 weeks of anti-toxoplasma therapy, the disease involuted. Retinal vascular occlusions and multifocal retinitis with perivascular sheathing are rare in toxoplasmosis. This is the first case report of toxoplasmic CRAO and multifocal retinitis with perivascular sheathing. The diagnosis of ocular toxoplasmosis should be considered in patients with retinal artery occlusions and multifocal retinitis with perivascular sheathing associated with inflammation.Keywords: ocular toxoplasmosis, toxoplasma retinochoroiditis, retinal vascular occlusion, polymerase chain reaction, vitrectomyArai HSakai TOkano KAoyagi RImai ATakase HMochizuki MTsuneoka HDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 789-792 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Arai H Sakai T Okano K Aoyagi R Imai A Takase H Mochizuki M Tsuneoka H Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing
description	Haruka Arai,1 Tsutomu Sakai,1 Kiichiro Okano,1 Ranko Aoyagi,1 Ayano Imai,2 Hiroshi Takase,2 Manabu Mochizuki,2 Hiroshi Tsuneoka11Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, JapanAbstract: Central retinal artery occlusion (CRAO) and multifocal retinitis with perivascular sheathing are rare in ocular toxoplasmosis. We report a case of toxoplasmic CRAO and multifocal retinitis with perivascular sheathing. A healthy 83-year-old male developed left panuveitis. Funduscopic examination of the left eye showed a swollen optic disc and sheathing of the retinal artery with a dense vitreous haze and a white retinal lesion. Serum anti-toxoplasma antibodies were positive in a latex agglutination assay. Vitrectomy was performed to improve visualization of the retinal lesions and for examination of causative microorganisms. A postoperative fundus examination revealed CRAO with optic disc involvement and multifocal retinitis with perivascular sheathing. Qualitative multiplex polymerase chain reaction detected the Toxoplasma gondii B1 gene in ocular fluid from both the aqueous and vitreous humor. The presumed diagnosis of ocular toxoplasmosis was made and treatment was started with prednisone and acetylspiramycin with subsequent improvement. Two months later, the patient developed active retinochoroiditis in the left eye. After 6 weeks of anti-toxoplasma therapy, the disease involuted. Retinal vascular occlusions and multifocal retinitis with perivascular sheathing are rare in toxoplasmosis. This is the first case report of toxoplasmic CRAO and multifocal retinitis with perivascular sheathing. The diagnosis of ocular toxoplasmosis should be considered in patients with retinal artery occlusions and multifocal retinitis with perivascular sheathing associated with inflammation.Keywords: ocular toxoplasmosis, toxoplasma retinochoroiditis, retinal vascular occlusion, polymerase chain reaction, vitrectomy
format	article
author	Arai H Sakai T Okano K Aoyagi R Imai A Takase H Mochizuki M Tsuneoka H
author_facet	Arai H Sakai T Okano K Aoyagi R Imai A Takase H Mochizuki M Tsuneoka H
author_sort	Arai H
title	Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing
title_short	Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing
title_full	Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing
title_fullStr	Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing
title_full_unstemmed	Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing
title_sort	presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/2884227b7ed34cb59168e4a010661374
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Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing

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