Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor and DNA bound cGAS crystal structures, which will f...

Full description

Saved in:
Bibliographic Details
Main Authors: Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/2885ccbed5fa465f9f9e037a1d7866c1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/2885ccbed5fa465f9f9e037a1d7866c1

Similar Items