Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases.

Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases.

Rabbits are widely used in biomedical research, yet techniques for their precise genetic modification are lacking. We demonstrate that zinc finger nucleases (ZFNs) introduced into fertilized oocytes can inactivate a chosen gene by mutagenesis and also mediate precise homologous recombination with a...

Full description

Saved in:
Bibliographic Details
Main Authors: Tatiana Flisikowska, Irmgard S Thorey, Sonja Offner, Francesca Ros, Valeria Lifke, Bryan Zeitler, Oswald Rottmann, Anna Vincent, Lei Zhang, Shirin Jenkins, Helmut Niersbach, Alexander J Kind, Philip D Gregory, Angelika E Schnieke, Josef Platzer
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/28865b2f7cbb4665ba7b4622b6f2e4fd
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/28865b2f7cbb4665ba7b4622b6f2e4fd

Similar Items