Immunomodulatory role of Keratin 76 in oral and gastric cancer

Keratin 76 (Krt76) is an epithelial differentiation marker that is downregulated in oral squamous cell carcinomas, correlating with poor prognosis. Here the authors show that genetic ablation of Krt76 in a mouse model results in increased susceptibility to carcinogenesis via enhanced accumulation of...

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Autores principales:	Inês Sequeira, Joana F. Neves, Dido Carrero, Qi Peng, Natalia Palasz, Kifayathullah Liakath-Ali, Graham M. Lord, Peter R. Morgan, Giovanna Lombardi, Fiona M. Watt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2887a9969f3b4463a91cb5977cdb295e
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spelling	oai:doaj.org-article:2887a9969f3b4463a91cb5977cdb295e2021-12-02T14:41:16ZImmunomodulatory role of Keratin 76 in oral and gastric cancer10.1038/s41467-018-05872-42041-1723https://doaj.org/article/2887a9969f3b4463a91cb5977cdb295e2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05872-4https://doaj.org/toc/2041-1723Keratin 76 (Krt76) is an epithelial differentiation marker that is downregulated in oral squamous cell carcinomas, correlating with poor prognosis. Here the authors show that genetic ablation of Krt76 in a mouse model results in increased susceptibility to carcinogenesis via enhanced accumulation of Tregs.Inês SequeiraJoana F. NevesDido CarreroQi PengNatalia PalaszKifayathullah Liakath-AliGraham M. LordPeter R. MorganGiovanna LombardiFiona M. WattNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Inês Sequeira Joana F. Neves Dido Carrero Qi Peng Natalia Palasz Kifayathullah Liakath-Ali Graham M. Lord Peter R. Morgan Giovanna Lombardi Fiona M. Watt Immunomodulatory role of Keratin 76 in oral and gastric cancer
description	Keratin 76 (Krt76) is an epithelial differentiation marker that is downregulated in oral squamous cell carcinomas, correlating with poor prognosis. Here the authors show that genetic ablation of Krt76 in a mouse model results in increased susceptibility to carcinogenesis via enhanced accumulation of Tregs.
format	article
author	Inês Sequeira Joana F. Neves Dido Carrero Qi Peng Natalia Palasz Kifayathullah Liakath-Ali Graham M. Lord Peter R. Morgan Giovanna Lombardi Fiona M. Watt
author_facet	Inês Sequeira Joana F. Neves Dido Carrero Qi Peng Natalia Palasz Kifayathullah Liakath-Ali Graham M. Lord Peter R. Morgan Giovanna Lombardi Fiona M. Watt
author_sort	Inês Sequeira
title	Immunomodulatory role of Keratin 76 in oral and gastric cancer
title_short	Immunomodulatory role of Keratin 76 in oral and gastric cancer
title_full	Immunomodulatory role of Keratin 76 in oral and gastric cancer
title_fullStr	Immunomodulatory role of Keratin 76 in oral and gastric cancer
title_full_unstemmed	Immunomodulatory role of Keratin 76 in oral and gastric cancer
title_sort	immunomodulatory role of keratin 76 in oral and gastric cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2887a9969f3b4463a91cb5977cdb295e
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Immunomodulatory role of Keratin 76 in oral and gastric cancer

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